Structure and oligomeric state of the mammalian tumour-associated antigen UK114.

Deriu D; Briand C; Mistiniene ENaktinis VGrutter MG

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Structure and oligomeric state of the mammalian tumour-associated antigen UK114.

机译：哺乳动物的结构和低聚物的状态肿瘤相关抗原UK114。

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The tumour-associated antigen UK114, isolated from goat liver, belongs to the YER057c/YIL051c/YjgF protein family, which has members in both the prokaryotes and eukaryotes. The crystal structure of a mammalian representative, goat UK114, was determined, revealing a trimeric arrangement in the crystal. It was confirmed by ultracentrifugation that UK114 is a trimer in solution. These results are in agreement with the published structures of homologues from unicellular organisms, but contrast with those reported for the rat homologue of UK114, for which a dimeric quaternary structure was proposed.

机译：肿瘤相关抗原UK114隔绝山羊肝脏,属于YER057c / YIL051c / YjgF蛋白家族的成员原核生物和真核生物。哺乳动物的代表,山羊UK114,决定,露出三聚物的安排水晶。超速离心法UK114是三聚物解决方案。发表同系物的结构单细胞生物,但与那些UK114鼠同系物的报道,一个二聚的四级结构是什么建议。

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《Acta crystallographica.Section D. Biological crystallography》 |2003年第9期|1676-1678|共3页
作者
Deriu D; Briand C; Mistiniene ENaktinis VGrutter MG;
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作者单位

Institute of Biochemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.;

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原文格式 PDF
正文语种英语
中图分类化学;
关键词
Tumor Antigens; Mammalia; GoatsRIDA geneantigensUltracentrifugationQuaternary Protein Structure;

机译：geneantigensUltracentrifugationQuaternary蛋白质结构;

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Structure and oligomeric state of the mammalian tumour-associated antigen UK114.

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