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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state.
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Structures of human oxy- and deoxyhaemoglobin at different levels of humidity: variability in the T state.

机译：人类氧和deoxyhaemoglobin结构不同级别的湿度:可变性T状态。

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摘要

High-salt crystals of human oxy- and deoxyhaemoglobin have been studied at different levels of environmental humidity and solvent content. The structure of the oxy form remains relatively unchanged at all levels. The deoxy form, however, undergoes a water-mediated transformation when the relative humidity around the crystals is reduced below 93%. The space group is maintained during the transformation, but the unit-cell volume nearly doubles, with two tetrameric molecules in the asymmetric unit of the low-humidity form compared with one in the native crystals. Interestingly, the haem geometry in the low-humidity form is closer to that in the oxy form than to that in the native deoxy form. The quaternary structure of one of the tetramers moves slightly towards that in the oxy form, while that in the other is more different from the oxy form than that in the high-salt native deoxy form. Thus, it would appear that, as in the case of the liganded form, the deoxy form of haemoglobin can also access an ensemble of related T states.
机译：人类氧和高盐晶体deoxyhaemoglobin一直在研究不同水平的环境湿度和溶剂内容。各级相对不变。形式,然而,经历了一个water-mediated转换时相对湿度水晶降低至93%以下。在转换的过程中,保持集团但单胞体积几乎翻倍,有两个四聚物的分子的不对称单位与一个在低湿度形式相比原生晶体。在低湿度接近的形式含氧的形式比在本地脱氧的形式。一个四聚体的四级结构动作稍微对氧的形式,而在另一个更加不同含氧的形式比高盐脱氧的形式。的配位形式,脱氧的形式血红蛋白也可以访问的合奏相关的T。

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