Oligonucleotides with 1,5-anhydrohexitol nucleoside building blocks: crystallization and preliminary X-ray studies of h(GTGTACAC).

Declercq R; Herdewijn P; Van Meervelt LVan Aerschot A

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Oligonucleotides with 1,5-anhydrohexitol nucleoside building blocks: crystallization and preliminary X-ray studies of h(GTGTACAC).

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Oligonucleotides with 1,5-anhydrohexitol nucleoside building blocks: crystallization and preliminary X-ray studies of h(GTGTACAC).

机译：寡核苷酸,5-anhydrohexitol核苷构建块:结晶初步的x射线研究h (GTGTACAC)。

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Hexitol nucleic acids are oligonucleotides built up from natural nucleobases and a phosphorylated 1,5-anhydrohexitol backbone. The anhydrohexitol oligonucleotide h(GTGTACAC) was synthesized using phosphoramidite chemistry and standard protecting groups. Crystals of h(GTGTACAC) were obtained at either 279 or 289 K by the hanging-drop vapour-diffusion technique using a 24-matrix screen for nucleic acid fragments. The crystals diffract beyond 2.0 A resolution and belong to the hexagonal space group P6222 (or P6422) with unit-cell parameters a = 36.42 and c = 63.33 A.

机译：己糖醇是核酸寡核苷酸从天然碱基和磷酸化1,5-anhydrohexitol backbone .合成寡核苷酸h (GTGTACAC)使用phosphoramidite化学和标准的保护组。279或289 K的悬滴使用24-matrix vapour-diffusion技术屏幕上的核酸片段。衍射分辨率和属于2.0之外六角空间群P6222(或P6422)晶胞参数= 36.42和63.33 c =。

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《Acta crystallographica.Section D. Biological crystallography》 |1999年第1期|279-280|共2页
作者
Declercq R; Herdewijn P; Van Meervelt LVan Aerschot A;
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Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Heverlee, Belgium.;

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正文语种英语
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Nucleic acids; Oligonucleotides; CrystallographycrystalsOligodeoxyribonucleotidesBase SequenceX-raysCrystallization;

机译：核酸,寡核苷酸;Crystallographycrys;

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Oligonucleotides with 1,5-anhydrohexitol nucleoside building blocks: crystallization and preliminary X-ray studies of h(GTGTACAC).

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