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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Complementing crystallography: the role of cryo-electron microscopy in structural biology.
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Complementing crystallography: the role of cryo-electron microscopy in structural biology.

机译：补充晶体学:所扮演的角色低温电子显微镜在结构生物学。

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摘要

Dramatic improvements in experimental methods and computational techniques have revolutionized three-dimensional image reconstruction from electron micrographs (EM) of vitrified samples. Recent results include the first determination of a protein fold (for the core protein of the hepatitis B virus) by non-crystalline imaging techniques. These developments have generated interest within the crystallographic community and have led to a re-evaluation of the technique, particularly amongst those working in the field of virus structure or struggling with the phasing of large macromolecular assemblies. A simple discussion of the techniques of EM image reconstruction and its advantages and problems in terms familiar to crystallographers will hopefully allow an appreciation of the essential complementarity of the two techniques and the practical potentials for phasing applications.
机译：实验方法和戏剧性的改善计算技术已经彻底改变了三维图像重建电子显微图(EM)的陶瓷样品。最近的结果包括第一的决心蛋白质折叠(的核心蛋白质乙型肝炎病毒)非晶的成像技术。在晶体社区的兴趣并引发了重新评估的技术,特别是在那些在地里干活病毒的结构或逐步陷入困境大型大分子组装。讨论了EM技术形象重建和其优势和存在的问题条件对晶体学家们会熟悉的希望允许一个升值的重要互补的两种技术实用潜力逐步应用。

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