Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood.

Grishkovskaya I; Avvakumov GV; Dales DBehlke JHammond GLMuller YASklenar G

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood.

【24h】

Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood.

机译：结晶的n端结构域的人类性hormone-binding球蛋白,主要性类固醇载体的血液。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The amino-teminal laminin G-like domain of human sex hormone-binding globulin (SHBG), which contains the steroid-binding site and the dimerization domain, has been produced in Escherichia coli, purified to homogeneity and crystallized in complex with 5alpha--dihydrotestosterone (DHT) in two different crystal forms. Native data sets have been collected for tetragonal crystals (space group P4(1)22 or P4(3)22; unit-cell parameters a = 52.2, c = 148.4 A) diffracting to 3.3 A and trigonal crystals (R32; a = 104.0, c = 84.4 A) diffracting to better than 1.6 A. Since both crystal forms can only accommodate a single monomer in the asymmetric unit and share twofold rotational symmetry, it is proposed that the homodimer of this truncated form of SHBG, as observed in ultracentrifugation experiments, displays C(2) point-group symmetry.

机译：的amino-teminal层粘连蛋白G-like域的人类性hormone-binding球蛋白,含有类固醇结合网站和二聚作用域,已经生产的大肠杆菌、纯化和同质性在复杂的结晶5α-二氢睾酮(DHT)两种不同的晶体形式。收集了正方晶体(空间组P4(1) 22或P4 (3) 22;= 52.2, c = 148.4和3.3)中三方晶系的晶体(R32;衍射比1.6更好。只能容纳单个晶体形式单体的不对称单元和双重的分享旋转对称,提出为截短形式的SHBG的观察到在超速离心法实验中,显示C(2)对称点群。

著录项

来源
《Acta crystallographica.Section D. Biological crystallography》 |1999年第12期|2053-2055|共3页
作者
Grishkovskaya I; Avvakumov GV; Dales DBehlke JHammond GLMuller YASklenar G;
展开▼
作者单位

Forschungsgruppe Kristallographie, Max-Delbruck-Center for Molecular Medicine, 13092 Berlin, Germany.;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类
关键词
Human; Blood; Protein StructureTertiaryCrystallographyGonadal Steroid HormonescrystalshomodimerDomainX-raysSex Hormone-Binding GlobulinCrystallization;

机译：人类;血液蛋白质StructureTertiaryCrystallographyGonadal类固醇HormonescrystalshomodimerDomainX-raysSexHormone-Binding GlobulinCrystallization;

相似文献

外文文献
中文文献

1. Lower levels sex hormone-binding globulin independently associated with metabolic syndrome in pre-elderly and elderly men in China [J] . Xiao-Na Pang, Yu Hu, Ying Yuan, 老年心脏病学杂志（英文版） . 2013,第001期
2. Cloning and Sequence Analysis of Partial Exons of Sex Hormone Binding Globulin Gene in Pig [J] . LI Qing-gang 动物与饲料科学：英文版 . 2010,第005期
3. Adu Anthropometry; Body Composition; Body Mass Index; Exercise; Female; Humans; Male; Motor Activity; Questionnaires; School Health Services; Self Disclosure; Sex Factors; Southeastern United States; Students; Universities; Waist-Hip Ratio; Walking;*成年人; 人体测量术; 身体成分; 人体质量指数; 运动(Exercise); 运动活动; 问卷; 中小学生卫生保健服务; 自我揭露; 性别因素; 美国东南部; 学生; 大学; 步行 [J] . ern United States, Students, Universities Antiviral therapy . 2009,第6期

机译：Adu Anthropometry; Body Composition; Body Mass Index; Exercise; Female; Humans; Male; Motor Activity; Questionnaires; School Health Services; Self Disclosure; Sex Factors; Southeastern United States; Students; Universities; Waist-Hip Ratio; Walking;*成年人; 人体测量术; 身体成分; 人体质量指数; 运动(Exercise); 运动活动; 问卷; 中小学生卫生保健服务; 自我揭露; 性别因素; 美国东南部; 学生; 大学; 步行
4. Adaptation, Psychological; Administrative Personnel; Attitude of Health Personnel; Communication; Cooperative Behavior; Female; Humans; Interprofessional Relations; Leadership; Male; Nurse Administrators; Nurse's Role; Organizational Objectives; Power (Psychology); Professional Competence; Sex Factors;*适应, 心理学; 行政管理人员; 医务工作者的态度; 信息交流; 合作行为; 职业间关系; 领导; 护理管理人员; 组织目标; 权力(心理学); 专业能力; 性别因素 [J] . Microbial drug resistance: MDR : Mechanisms, epidemiology, and disease . 2009,第3期

机译：Adaptation, Psychological; Administrative Personnel; Attitude of Health Personnel; Communication; Cooperative Behavior; Female; Humans; Interprofessional Relations; Leadership; Male; Nurse Administrators; Nurse's Role; Organizational Objectives; Power (Psychology); Professional Competence; Sex Factors;*适应, 心理学; 行政管理人员; 医务工作者的态度; 信息交流; 合作行为; 职业间关系; 领导; 护理管理人员; 组织目标; 权力(心理学); 专业能力; 性别因素
5. Bayes Theorem; Confidence Intervals; France; Humans; Incidence; Income; Lung Neoplasms; Male; Middle Aged; Regression Analysis; Risk; Sex Factors; Socioeconomic Factors; Urban Population;*成年人; 年龄因素; 老年人; 老年人, 80以上; 贝叶斯定理; 置信区间; 法国; 发病率; 收入; 肺肿瘤; 回归分析; 危险; 性别因素; 社会经济因素; 市区人口 [J] . Quality of life research: An international journal of quality of life aspects of treatment, care and rehabilitation . 2009,第8期

机译：Bayes Theorem; Confidence Intervals; France; Humans; Incidence; Income; Lung Neoplasms; Male; Middle Aged; Regression Analysis; Risk; Sex Factors; Socioeconomic Factors; Urban Population;*成年人; 年龄因素; 老年人; 老年人, 80以上; 贝叶斯定理; 置信区间; 法国; 发病率; 收入; 肺肿瘤; 回归分析; 危险; 性别因素; 社会经济因素; 市区人口
6. Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of human coronavirus OC43 nucleocapsid protein [O] . Chen I.J., Chou C.C., Liu C.L., 2014

机译：Crystallization and preliminary X-ray diffraction analysis of the N-terminal domain of human coronavirus OC43 nucleocapsid protein

Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood.

摘要

著录项

相似文献

相关主题

期刊订阅