Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit.

Tang L; Lin ZJ; Zhou YC

首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit.

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Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit.

机译：结构agkistrodotoxin斜方晶系的每个不对称晶体形成有六个分子单位。

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The structure of agkistrodotoxin crystallized under basic conditions has been determined at 2.8 A resolution by the molecular-replacement technique and refined to a crystallographic R factor of 0.194 and a free R factor of 0.260 with good stereochemistry. The molecular packing in the crystal differs from other PLA(2)s. The six molecules in the asymmetric unit form three dimers linked by Ca(2+) ions in a near-perfect six-ligand octahedral coordinating system. Extensive intermolecular hydrophobic interactions occur at the interfacial recognition site of each neurotoxin molecule, which provides an insight into phospholipase A(2)-membrane interactions. This hydrophobic interaction-induced molecular association along the interfacial recognition site suggests a self-protection mechanism of agkistrodotoxin.

机译：agkistrodotoxin结晶的结构在基本条件下已确定为2.8由molecular-replacement决议技术和精制结晶R0.194倍和0.260 R因子与自由良好的立体化学。水晶不同于其他解放军(2)。三个分子不对称单元形式二聚体与Ca(2 +)离子在一个近乎完美的six-ligand八面体协调系统。广泛的分子间的疏水相互作用发生在界面识别网站神经毒素分子,这提供了一个洞察磷脂酶(2)膜的相互作用。这种疏水性interaction-induced分子沿着界面识别协会网站显示的一种自我保护机制agkistrodotoxin。

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《Acta crystallographica.Section D. Biological crystallography》 |1999年第12期|1986-1996|共11页
作者
Tang L; Lin ZJ; Zhou YC;
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National Laboratory of Biological Macromolecules, Institute of Biophysics, Academia Sinica, Beijing 100101, People's Republic of China.;

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正文语种英语
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关键词
Protein Structure; molecules; CrystallographyAnimalsdimerizationprotection mechanismcrystal outlineQuaternaryX-raysAgkistrodonCrystallization;

机译：蛋白质结构,分子;CrystallographyAnimals;

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Structure of agkistrodotoxin in an orthorhombic crystal form with six molecules per asymmetric unit.

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