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首页> 外文期刊>Acta crystallographica.Section D. Biological crystallography >Production of crystals of human aldose reductase with very high resolution diffraction.
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Production of crystals of human aldose reductase with very high resolution diffraction.

机译：生产人类醛糖还原酶的晶体高分辨率的衍射。

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摘要

As the action of human aldose reductase (hAR) is thought to be linked to the pathogenesis of diabetic complications, much effort has been directed towards the analysis of the catalytic mechanism and the development of specific inhibitors. Here, the crystallization of recombinant hAR with its cofactor NADP+ at 277 K in the presence of the precipitating agent PEG 6000 is reported. The crystals diffract to high resolution (1.1 A) and belong to the P21 space group with unit-cell parameters a = 49.97, b = 67.14, c = 48. 02 A, beta = 92.2 degrees with one molecule per asymmetric unit. Seleno-substituted hAR crystals were also produced and diffract to 1. 7 A on a conventional X-ray source.
机译：随着人类行动的醛糖还原酶(hAR)认为是发病机制有关糖尿病的并发症,多努力针对催化的分析机制和具体的发展抑制剂。重组哈尔的代数余子式辅酶ii + 277 K在沉淀剂的存在6000年报道。决议(1.1)和P21属于空间b组与晶胞参数= 49.97,=67.14, c = 48。分子/不对称单位。哈尔晶体也生产和衍射1.

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