Crystallization, characterization and measurement of MAD data on crystals of dengue virus NS3 serine protease complexed with mung-bean Bowman-Birk inhibitor.

Krishna Murthy HM; DeLucas L; Clum SPadmanabhan RJudge K

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Crystallization, characterization and measurement of MAD data on crystals of dengue virus NS3 serine protease complexed with mung-bean Bowman-Birk inhibitor.

机译：结晶、描述和测量疯狂的登革热病毒NS3晶体数据丝氨酸蛋白酶与绿豆Bowman-Birk抑制剂。

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Crystallization and preliminary characterization of the essential dengue virus NS3 serine protease complexed with a Bowman-Birk-type inhibitor from mung beans are reported. As the structure proved resistant to solution by molecular replacement and multiple isomorphous replacement methods, multi-wavelength anomalous diffraction data at the LIII edge of a holmium derivative have been measured. Promising Bijvoet and dispersive signals which are largely consistent with expected values have been extracted from the data. The structure, when determined, will provide a structural basis for the design, synthesis and evaluation of inhibitors of the protease for chemotherapy of dengue infections.

机译：结晶和初步表征基本的登革病毒NS3丝氨酸蛋白酶包裹着Bowman-Birk-type抑制剂绿豆是报道。耐药分子替代解决方案和多个同形的替代方法,多波长反常衍射数据钬LIII边缘的导数测量。信号在很大程度上是一致的预期值的提取数据。提供结构基础设计,抑制剂的合成和评价蛋白酶对化疗的登革热感染。

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《Acta crystallographica.Section D. Biological crystallography》 |1999年第7期|1370-1372|共3页
作者
Krishna Murthy HM; DeLucas L; Clum SPadmanabhan RJudge K;
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作者单位

Center for Macromolecular Crystallography, University of Alabama at Birmingham, 79-THT, MCLM-244, 1918 University Boulevard, Birmingham, AL 35294-0005, USA. murthy@onyx.cmc.uab.edu;

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正文语种英语
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Protein Conformation; Serine Proteinase; greengramCrystallographycrystalsDengue VirusTrypsin InhibitorsBowman Birk inhibitorX-raysNoonan syndrome 3CrystallizationDengue Fever;

机译：蛋白质构象;丝氨酸蛋白酶;greengramCrystallographycrystalsDengueinhibitorX-raysNoonan综合症3 crystallizationdengue发烧;

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Crystallization, characterization and measurement of MAD data on crystals of dengue virus NS3 serine protease complexed with mung-bean Bowman-Birk inhibitor.

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