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首页> 外文期刊>Archives of Internal Medicine >Ongoing improvement in outcomes for patients diagnosed as having Non-Hodgkin lymphoma from the 1990s to the early 21st century.
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Ongoing improvement in outcomes for patients diagnosed as having Non-Hodgkin lymphoma from the 1990s to the early 21st century.

机译：对病人持续改善的效果诊断的非霍奇金淋巴瘤1990年代到21世纪初。

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BACKGROUND: Non-Hodgkin lymphoma (NHL) is the most common hematologic malignant neoplasm in adults. We use the novel technique of period analysis to disclose the most recent trends in survival among adults diagnosed as having NHL on the population level with minimum delay. METHODS: We estimated trends in 5- and 10-year relative survival in patients 15 years or older diagnosed as having NHL in the United States between 1990 and 2004 using data from the Surveillance, Epidemiology, and End Results (SEER) program. We also estimated survival by age, location and histologic type of the tumor, sex, and race to further elucidate trends in survival in this disease. RESULTS: Overall, 5-year relative survival increased from 50.4% to 66.8%, and 10-year relative survival increased from 39.4% to 56.3% between 1990-1992 and 2002-2004. Improvements were most pronounced in patients younger than 45 years (+26.8 and +27.1 percentage points for 5- and 10-year survival, respectively), but improvements were seen in all age groups, in both sexes, in both nodal and extranodal disease, and in both low-grade and high-grade disease. Improvements in prognosis were less in black patients than in white patients, especially in younger black patients. CONCLUSIONS: Our period analysis discloses a strongly improved outlook for patients diagnosed as having NHL in recent years. Changes in treatment of the disease and a decrease in the number of human immunodeficiency virus-related NHL cases attributable to highly active antiretroviral therapy are probably primarily responsible for these improvements.
机译：背景:非霍奇金淋巴瘤(NHL)是最常见的血液系统恶性肿瘤的成年人。我们使用周期分析的新技术透露最近的趋势在生存成人诊断NHL的人口用最小的延迟。5年期和10年期相对生存的趋势患者15年或以上诊断为NHL在美国1990年和2004年之间使用的数据监测,流行病学,和最终结果(SEER)计划。生存的时代,位置和组织学类型肿瘤、性别和种族,进一步阐明生存在这个疾病的趋势。总的来说,生存5年相对增加50.4%到66.8%,10年期相对生存在1990 - 1992年从39.4%上升到56.3%和2002 - 2004。45岁以下的病人(+ 26.8+ 27.1的5年期和10年期分别为生存),但改进在所有年龄组中所看到的,在两种性别中,在两种节点和淋巴结外侵犯疾病,两者兼而有之低级和高级疾病。黑人患者的预后并不比白色的病人,尤其是在年轻的黑人病人。揭示强改进前景近年来被诊断为有NHL患者。疾病的治疗和变化减少人类免疫缺陷的数量病毒相关NHL案例归因于高度抗逆转录病毒疗法可能是主要负责这些改进。

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