• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Internal Medicine >Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data.
【24h】

Lipoprotein(a) levels and risk of future coronary heart disease: large-scale prospective data.

机译：脂蛋白(a)水平和未来冠心病的风险心脏病:大规模的前瞻性数据。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Large-scale prospective data are needed to determine whether associations between lipoprotein(a) (Lp[a]) and coronary heart disease (CHD) risk are independent of established risk factors, to characterize the shape of this relationship, and to quantify associations in relevant subgroups. METHODS: Levels of Lp(a) were measured in samples obtained at baseline from 2047 patients who had first-ever nonfatal myocardial infarction or who died of CHD during the study and from 3921 control participants in the Reykjavik Study (n=18 569), as well as in paired samples obtained 12 years apart from 372 participants to quantify within-person fluctuations. RESULTS: Baseline Lp(a) levels had little or no correlation with known cardiovascular risk factors, such as age, sex, total cholesterol level, and blood pressure. The Lp(a) values were highly consistent from decade to decade, with a regression dilution ratio (calculated on the log scale) of 0.92 (95% confidence interval, 0.85-0.99). The odds ratio for CHD, unaltered after adjustment for several established risk factors (age, sex, smoking status, blood pressure, total cholesterol, triglycerides level, diabetes mellitus, and body mass index), was 1.60 (95% confidence interval, 1.38-1.85) in a comparison of extreme thirds of baseline Lp(a) levels. Odds ratios were progressively higher with increasing Lp(a) levels and did not vary materially by several individual- or study-level characteristics. CONCLUSIONS: There are independent, continuous associations between Lp(a) levels and risk of future CHD in a broad range of individuals. Levels of Lp(a) are highly stable within individuals across many years and are only weakly correlated with known risk factors. Further assessment of their possible role in CHD prevention is warranted.
机译：背景:大规模的前瞻性数据需要确定之间的关联脂蛋白(a) (Lp [a])和冠心病(冠心病)风险是建立独立的风险因素,来形容它的形状关系,量化关联相关的子组。以样本获得的基线2047患者首次非致命的心肌梗死或死于冠心病该研究从3921年开始参与控制雷克雅未克的研究(n = 18 569),以及在配对样本获得12年除了372参与者量化within-person波动。与已知的很少或没有相关性心血管风险因素,如年龄、性别、总胆固醇水平和血压。Lp (a)从十年价值观高度一致十年,回归稀释比例(计算对数尺度)0.92 (95%置信区间,0.85 - -0.99)。冠心病,调整后的数建立风险因素(年龄、性别、是否吸烟状态、血压、总胆固醇、甘油三酸酯水平,糖尿病,和身体质量指数)为1.60(95%置信区间,1.38 - -1.85)在一个比较极端的三分之二基线Lp (a)水平。逐步增加Lp (a)水平较高,没有物质由几个不同个人,或者学习水平的特点。结论:有独立的、连续的Lp (a)水平和风险之间的关联未来冠心病广泛的个人。Lp (a)水平高度稳定个人在许多年,只是弱与已知的危险因素。评估其可能在冠心病中的作用预防是必要的。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号