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首页> 外文期刊>Archives of Internal Medicine >Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women.
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Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women.

机译：坚持DASH-style饮食和风险女性冠状动脉心脏病和中风。

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BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet has been shown to lower blood pressure, but little is known about its long-term effect on cardiovascular end points. Our objective was to assess the association between a DASH-style diet adherence score and risk of coronary heart disease (CHD) and stroke in women. METHODS: In this prospective cohort study, diet was assessed 7 times during 24 years of follow-up (1980-2004) with validated food frequency questionnaires. A DASH score based on 8 food and nutrient components (fruits, vegetables, whole grains, nuts and legumes, low-fat dairy, red and processed meats, sweetened beverages, and sodium) was calculated. Lifestyle and medical information was collected biennially with a questionnaire. The Cox proportional hazard model was used to adjust for potential confounders. The study population comprised 88,517 female nurses aged 34 to 59 years without a history of cardiovascular disease or diabetes in 1980. The main outcome measures were the numbers of confirmed incident cases of nonfatal myocardial infarction, CHD death, and stroke. RESULTS: We documented 2129 cases of incident nonfatal myocardial infarction, 976 CHD deaths, and 3105 cases of stroke. After adjustment for age, smoking, and other cardiovascular risk factors, the relative risks of CHD across quintiles of the DASH score were 1.0, 0.99, 0.86, 0.87, and 0.76 (95% confidence interval, 0.67-0.85) (P<.001 for trend). The magnitude of risk difference was similar for nonfatal myocardial infarction and fatal CHD. The DASH score was also significantly associated with lower risk of stroke (multivariate relative risks across quintiles of the DASH score were 1.0, 0.92, 0.91, 0.89, and 0.82) (P=.002 for trend). Cross-sectional analysis in a subgroup of women with blood samples showed that the DASH score was significantly associated with lower plasma levels of C-reactive protein (P=.008 for trend) and interleukin 6 (P=.04 for trend). CONCLUSION: Adherence to the DASH-style diet is associated witha lower risk of CHD and stroke among middle-aged women during 24 years of follow-up.
机译：背景:饮食方法停止高血压(DASH)饮食已被证实能够降低血压,但对其所知甚少长期影响心血管终点。我们的目标是评估协会DASH-style饮食依从性得分和之间冠心病(CHD)和中风的风险在女性。研究中,饮食是评估7 * 24年期间后续(1980 - 2004)的食品进行验证频率的问卷调查。食品和营养成分(水果,蔬菜,全谷物、坚果和豆类,低脂牛奶,红肉和加工肉类、加糖饮料和钠)计算。信息收集每两年了问卷调查。是用来调整潜在的混杂因素。研究人口由88517名女护士34岁至59岁的历史1980年心血管疾病或糖尿病。主要结果测量的数量确认事故情况下的非致死性心肌梗塞,冠心病死亡,和中风。记录了2129例非致命的事件冠心病心肌梗死,976死亡,3105人中风的病例。吸烟和其他心血管危险因素,在昆泰的冠心病的相对风险DASH得分是1.0,0.99,0.86,0.87和0.76(95%置信区间,0.67 - -0.85)(P <。趋势)。非致死性心肌梗死和相似致命的冠心病。降低患中风的风险(多元在昆泰的相对风险DASH得分是1.0,0.92,0.91,0.89,(P = 0.82)。分析小组的女性的血液样本显示,DASH得分显著降低血浆水平c反应蛋白(P =。白介素6 (P =。坚持DASH-style饮食有关一种降低冠心病和中风的风险随访24年的中年妇女。

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