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首页> 外文期刊>Archives of Internal Medicine >The joint effects of physical activity and body mass index on coronary heart disease risk in women.
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The joint effects of physical activity and body mass index on coronary heart disease risk in women.

机译：的联合影响身体活动和身体质量指数对冠心病的风险女性。

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BACKGROUND: Physical activity and body mass index (calculated as weight in kilograms divided by height in meters squared) independently alter the risk of coronary heart disease (CHD); however, their combined effect on CHD is not established. Our objective was to study the combined association of physical activity and body mass index on CHD. METHODS: Prospective cohort study of 38,987 women free of cardiovascular disease, cancer, and diabetes at baseline in the Women's Health Study, with 10.9 mean years of follow-up. Weight, height, and recreational activities were reported on entry. Body mass index was categorized as normal weight ( or =30). Active was defined as 1000 kilocalories or more expended on recreational activities weekly. Six joint body weight-physical activity categories were defined. The main outcome measure was the occurrence of incident CHD during follow-up, defined as a cardiovascular event including nonfatal myocardial infarction, coronary artery bypass graft, percutaneous transluminal coronary angioplasty, or CHD death. RESULTS: A total of 948 cases of incident CHD occurred during follow-up. Higher body mass index and physical inactivity were individual predictors of CHD. In joint analyses, compared with active normal-weight individuals, the multivariate-adjusted hazard ratios (95% confidence intervals) were 1.54 (1.14-2.08) for overweight-active; 1.87 (1.29-2.71) for obese-active; 1.08 (0.84-1.39) for normal weight-inactive; 1.88 (1.46-2.42) for overweight-inactive; and 2.53 (1.94-3.30) for obese-inactive. Increasing levels of walking also resulted in significant reductions in CHD risk for overweight and obese individuals. CONCLUSIONS: The risk of CHD associated with elevated body mass index is considerably reduced by increased physical activity levels. However, the risk is not completely eliminated, reinforcing the importance of being lean and physically active.
机译：背景:身体活动和身体质量指数(计算单位为千克的重量除以身高(米平方)独立地改变冠心病(CHD)的风险;他们的结合对冠心病的影响不确定。我们的目标是研究相结合协会的身体活动和身体质量指数在冠心病。心血管疾病的38987名女性的自由,癌症和糖尿病在女性的基线健康研究,10.9年的随访。体重、身高、和娱乐活动报道了条目。分类为正常体重( = 30)。定义为1000千卡以上消耗每周娱乐活动。weight-physical活动类别被定义。主要结果测量的发生冠心病事件在随访中,定义为一个心血管事件包括非致死性心肌梗死、冠状动脉搭桥贪污,经皮穿冠状血管成形术或冠心病死亡。948例冠心病事件发生时随访。不活动是个体预测冠心病。联合分析,而活跃正常体重的人,multivariate-adjusted风险比率(95%置信区间)1.54 (1.14 - -2.08)overweight-active;obese-active;weight-inactive;overweight-inactive;obese-inactive。导致显著减少冠心病的风险超重和肥胖的人。结论:冠心病的风险联系在一起高身体质量指数会大大减少通过增加身体活动水平。风险不能完全消除,加强精益和的重要性体力活动。

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