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首页> 外文期刊>Archives of Internal Medicine >Exposure to particulate air pollution and risk of deep vein thrombosis.
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Exposure to particulate air pollution and risk of deep vein thrombosis.

机译：暴露于空气颗粒物污染的风险深静脉血栓形成。

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BACKGROUND: Particulate air pollution has been linked to heart disease and stroke, possibly resulting from enhanced coagulation and arterial thrombosis. Whether particulate air pollution exposure is related to venous thrombosis is unknown. METHODS: We examined the association of exposure to particulate matter of less than 10 microm in aerodynamic diameter (PM10) with deep vein thrombosis (DVT) risk in 870 patients and 1210 controls from the Lombardy region in Italy, who were examined between 1995 and 2005. We estimated exposure to PM10 in the year before DVT diagnosis (cases) or examination (controls) through area-specific mean levels obtained from ambient monitors. RESULTS: Higher mean PM10 level in the year before the examination was associated with shortened prothrombin time (PT) in DVT cases (standardized regression coefficient [beta] = -0.12; 95% confidence interval [CI], -0.23 to 0.00) (P = .04) and controls (beta = -0.06; 95% CI, -0.11 to 0.00) (P = .04). Each increase of 10 microg/m3 in PM10 was associated with a 70% increase in DVT risk (odds ratio [OR], 1.70; 95% CI, 1.30 to 2.23) (P < .001) in models adjusting for clinical and environmental covariates. The exposure-response relationship was approximately linear over the observed PM10 range. The association between PM10 level and DVT risk was weaker in women (OR, 1.40; 95% CI, 1.02 to 1.92) (P = .02 for the interaction between PM10 and sex), particularly in those using oral contraceptives or hormone therapy (OR, 0.97; 95% CI, 0.58 to 1.61) (P = .048 for the interaction between PM10 level and hormone use). CONCLUSIONS: Long-term exposure to particulate air pollution is associated with altered coagulation function and DVT risk. Other risk factors for DVT may modulate the effect of particulate air pollution.
机译：背景:微粒空气污染导致心脏病和中风,可能造成增强凝血和动脉血栓形成。暴露与静脉血栓形成未知的。接触不到10的颗粒物microm在空气动力学直径(PM10)深静脉血栓形成(DVT) 870例和风险1210年意大利伦巴第地区的控制,他们研究了1995年和2005年之间。今年估计暴露在可吸入颗粒物在深静脉血栓形成诊断(例)或考试(控制)我们采取具有地域特点通过工作获得的平均水平环境监测。在前一年考试有关缩短凝血酶原时间(PT)在深静脉血栓形成病例(标准化回归系数(β)=-0.12;0.00) (P = .04点)和控制(β= -0.06;CI, -0.11 - 0.00) (P = .04点)。microg / m3在可吸入颗粒物是70%深静脉血栓形成的风险增加(优势比[或],1.70;CI, 1.30 - 2.23) (P <措施)在模型中调整临床和环境协变量。我们的关系大约是在观察到PM10线性范围。可吸入颗粒物水平和深静脉血栓形成的风险之间的联系较弱的女性(OR, 1.40;(P = .02 PM10和之间的交互性),特别是那些使用口服避孕药或激素治疗(or, 0.97;CI, 0.58 - 1.61) (P = .048交互可吸入颗粒物之间的水平和激素的使用)。长期暴露在微粒空气污染与凝血功能改变有关和深静脉血栓形成的风险。调节空气颗粒物污染的影响。

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