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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >CD1a positive putative tumour infiltrating dendritic cells in human breast cancer.
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CD1a positive putative tumour infiltrating dendritic cells in human breast cancer.

机译：CD1a阳性推定的肿瘤浸润人乳腺癌中的树突状细胞。

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摘要

CD1a molecules are expressed on dendritic cells (DC) during certain maturational phases coincident with the functions of antigen capture and processing. During these phases, CD1a is anchored to the cytoplasmic membrane through its cytoplasmic domain and the antigenic binding domain is projected from the cell surface. Membrane bound HLA Class I and II molecules are also expressed at relatively high levels on DC, but it is not known whether there is any interdependence between CD1 expression and that of the classical histocompatability molecules. Recent information concerning the structure, function and likely role of CD1 in presentation of hydrophobic lipid and carbohydrate antigens to the immune system is detailed. The potential relevance of the lipid presenting functions of CD1 molecules for the detection and recognition of tumour glycolipid antigens is hypothesised and discussed. CD1 a tumour infiltrating putative dendritic cells are discussed in terms of their density, separation, culture and possible function in breast cancers in the light of recent findings.
机译：CD1a分子在某些成熟阶段在树突状细胞（DC）上表达，这与抗原捕获和加工的功能一致。在这些阶段中，CD1a通过其胞质结构域锚定在胞质膜上，抗原结合结构域从细胞表面突出。膜结合的HLA I类和II类分子也在DC上以相对较高的水平表达，但尚不知道CD1表达与经典组织相容性分子之间是否存在任何相互依赖性。详细介绍了有关CD1在疏水性脂质和碳水化合物抗原向免疫系统呈递中的结构，功能和可能作用的最新信息。假设和讨论了CD1分子的脂质呈递功能对肿瘤糖脂抗原的检测和识别的潜在相关性。鉴于最近的发现，从肿瘤的密度，分离，培养和在乳腺癌中的可能功能方面讨论了CD1a肿瘤浸润性树突状细胞。

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