The impact of biotin interference on laboratory testing and patient diagnosis in clinical practice

Luca Giovanella

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The impact of biotin interference on laboratory testing and patient diagnosis in clinical practice

机译：在实验室生物素干扰的影响测试和病人在临床诊断实践

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Biotin-streptavidin coupling has been utilized for decades by diagnostic immunoassay manufacturers. However, concerns have been raised regarding the risk of biotin interference with biotin/streptavidin-based immunoassays due to the use of high-dose biotin in cosmetic supplements, and treatments for multiple sclerosis [1-4], and some inherited metabolic diseases (e.g., biotinidase, multiple carboxylase and holocarboxylase synthetase deficiencies) [5]. A recent study characterized the biotin pharmacokinetic profile in healthy participants following high-dose biotin administration and provided guidance on washout periods to avoid false assay results from biotin interference [6].Here, we discuss the prevalence of assay interferences, particularly biotin interference, consider its impact on clinical practice, and suggest potential strategies to reduce this impact and ensure accurate patient diagnosis.

机译：利用已有Biotin-streptavidin耦合几十年的诊断免疫测定制造商。然而,已经产生的疑虑生物素干扰的风险生物素/ streptavidin-based分析由于化妆品中使用高剂量生物素补充剂,和治疗多发性硬化[1 - 4]某些遗传性代谢疾病(例如,多种羧化酶和biotinidaseholocarboxylase合成酶缺陷)[5]。最近的研究是生物素药代动力学在健康的参与者后高剂量生物素和管理为了避免提供指导冲刷时期错误的生物素干扰测定结果[6]。干扰,特别是生物素干扰,考虑其对临床实践的影响,建议减少这种潜在的策略影响病人的诊断,确保准确。

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来源
《International journal of pharmacokinetics.》 |2019年第1期|1-4|共4页
作者
Luca Giovanella;
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作者单位

Clinic for Nuclear Medicine & Competence Centre for Thyroid Diseases, Imaging Institute of Southern;

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原文格式 PDF
正文语种英语
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关键词
clinical practice; laboratory procedure; Biotinpatient diagnosisImmunologic TechniqueImmunoassay;

机译：实验室临床实践;程序;Biotinpatient diagnosisImmunologic;

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The impact of biotin interference on laboratory testing and patient diagnosis in clinical practice

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