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首页> 外文期刊>International journal of pharmacokinetics. >Comparison of pharmacokinetic parameters of mycophenolic acid in two groups of Iranian kidney transplant patients
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Comparison of pharmacokinetic parameters of mycophenolic acid in two groups of Iranian kidney transplant patients

机译：比较药代动力学参数霉酚酸在两组伊朗肾脏器官移植患者

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Aim: Mycophenolate mofetil is widely used in organ transplantation to prevent acute rejection. Following oral administration, it is rapidly converted to mycophenolic acid (MPA). Effectiveness and the incidence of rejection is influenced by area under the concentration-time curve (AUC). Effect of time after transplantations on pharmacokinetic (PK) parameters is considered. Method: PK parameters of MPA was characterized in two different groups of Iranian kidney transplant patients. MPA plasma concentrations following oral administration of 1 g mycophenolate mofetil in a multiple dosage regimen were measured in 21 (group 1) and 31 (group 2) individuals. Group 1 for more than 3 months and group 2 had been transplanted for 9-10 days. Blood samples were taken before and at different time points following dose administration (0-12 h). Peak plasma concentration (C_(max)), time to reach C_(max) (T_(max)), and AUC were calculated for each patient. Results: The first plasma peak was reached in the range of 0.6-2 and 0.3-2 h following dose intake in group 1 and group 2, respectively. In group 1, AUC, C_(max)and time to reach C_(max) were 47.6 ± 18.4 mug.h/ml, 17.9 ± 9.2 mug/ml and 1.0 ± 0.6 h respectively. In the second group, these values were 26.6 ± 19.0 mug.h/ml, 9.3 ± 6.1 mug/ml and 0.7 ± 0.6 h, respectively. Elimination rate constants were calculated for all the patients. In most of the patients, the three terminal points made the reliable results. Conclusion: The differences between PK parameters in these groups may be related to the length of time after transplantation and this must be considered in dose adjustment, probably decreasing the dose after few months to half and these may be performed in a proper clinical trial design.
机译：目的:霉酚酸酯广泛用于器官防止急性移植排斥。口服后,迅速转换成霉酚酸(MPA)。有效性和排斥反应的发生率受浓度时间下的面积的影响曲线(AUC)。移植在药代动力学(PK)参数被认为是。MPA的特点是在两个不同的组伊朗的肾移植患者。口服后浓度为1克霉酚酸酯在多个剂量养生法测定21(组1)和31(组2)人。个月,移植了9组2天。剂量后不同时间点政府(他一直h)。等离子体达到顶峰浓度(C_ (max)),时间达到C_ (max)(T_ (max)识别),AUC计算病人。在0.6 - 2和0.3 - 2 h的范围剂量组1、组2中摄入后,分别。达到C_ (max)分别为47.6±18.4 mug.h /毫升,17.9±9.2杯/毫升,分别为1.0±0.6 h。第二组,这些值分别为26.6±19.0mug.h / ml, 9.3±6.1杯/毫升和0.7±0.6 h,分别。计算出所有的病人。患者,分了三个终端可靠的结果。在这些团体可能之间的PK参数相关的时间长度移植,这必须考虑剂量调整,可能减少剂量几个月后,这些可能是一半执行一个适当的临床试验设计。

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