Aggrecanase: The Family and Its Inhibitors

R.-Q. Liu; J.M. Trzaskos

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Aggrecanase: The Family and Its Inhibitors

机译：Aggrecanase:家庭和其抑制剂

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摘要

Osteoarthritic joint disease is characterized by the progressive loss of articular cartilage resulting in functional impairment, pain and discomfort. The major components in cartilage, collagen and aggrecan, are lost during disease through the action of degradative proteolytic enzymes, The proteases responsible for aggrecan degradation are termed ag-grecanases. The aggrecanases represent a family of enzymes with great therapeutic potential as targets for the treatment of osteoarthritis. Here we review the family of aggrecanases and the progress made toward the identification of potent and selective enzyme inhibitors for use as therapeutic agents.

机译：骨关节炎的关节疾病的特点是关节软骨的逐步丧失导致功能障碍、疼痛和不适。胶原蛋白和aggrecan期间丧失的疾病通过降解蛋白水解的作用酶,蛋白酶aggrecan负责称为ag-grecanases退化。aggrecanases代表一个家庭的酶未来的治疗目标治疗骨关节炎。家庭aggrecanases和所取得的进展向强有力的和选择性的识别酶抑制剂用于治疗药物。

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《Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents》 |2005年第3期|251-264|共14页
作者
R.-Q. Liu; J.M. Trzaskos;
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作者单位

Inflammation and Immunology Biology, Pharmaceutical Research Institute, Bristol Myers Squibb Co Princeton, NJ 08540, USA;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Proteases; Collagenopathy, type 2 alpha 1; MMPOsteoarthritisCartilageAggrecansaggrecanaseEnzyme Inhibitorsfamily;

机译：蛋白酶;Collagenopathy 2型α1;MMPOsteoa;

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Aggrecanase: The Family and Its Inhibitors

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