Small-molecule chemokine receptor antagonists: potential targets for inflammatory and allergic disorders

Toshihiko Saeki

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Small-molecule chemokine receptor antagonists: potential targets for inflammatory and allergic disorders

机译：小分子趋化因子受体拮抗剂:潜在目标炎症和过敏障碍

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A substantial body of evidence suggests that blockade of chemokine-chemokine receptor interaction with potent small-molecule receptor antagonists may be a promising therapeutic intervention for inflammatory and allergic disorders in humans. A number of pharmaceutical companies have disclosed patents and journals regarding chemokine receptor antagonists with their pharmacological activities. Recently, some chemokine receptor antagonists have successfully progressed to clinical trials, and preliminary results have suggested effectiveness in treating in human disorders. This section highlights some representative and promising chemokine receptor antagonists targeting inflammatory and allergic disorders, and "proof of concept" studies in inflammatory and allergic disorders in animals and humans

机译：大量的证据表明,封锁chemokine-chemokine受体与有效的小分子受体对手可能是一个有前途的治疗干预炎症和过敏在人类疾病。公司披露专利和期刊有关趋化因子受体拮抗剂他们的药理活性。趋化因子受体拮抗剂已经成功临床试验进展,初步的结果表明在治疗有效性在人类疾病。代表和有前途的趋化因子受体对手针对炎症和过敏障碍和“概念验证”的研究炎症和过敏性疾病的动物和人类

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《Current medicinal chemistry-Anti-inflammatory & anti-allergy agents.Anti-inflammatory & anti-allergy agents》 |2004年第4期|363-375|共13页
作者
Toshihiko Saeki;
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作者单位

Tsukuba Research Institute, BANYU Pharmaceutical Co., Ltd. Okubo 3, Tsukuba, Ibaraki 300-2611, Japan;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Chemokine receptors; Inflammation; Clinical StudyChemokine Receptor Antagonistantagonists;

机译：趋化因子受体;炎症;临床StudyChemokine受体Antagonistantagonists;

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Small-molecule chemokine receptor antagonists: potential targets for inflammatory and allergic disorders

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