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首页> 外文期刊>Journal of endometriosis and pelvic pain disorders. >Abnormal pathways in endometriosis in relation to progesterone resistance: a review
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Abnormal pathways in endometriosis in relation to progesterone resistance: a review

机译：子宫内膜异位症与异常路径孕激素抵抗:审查

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Introduction: Endometriosis is an estrogen-dependent disorder, and recent studies suggest that progesterone resistance may contribute to the development and pathophysiology of the disorder. Based on this, identification of genetic and molecular perturbations in the endometrium of women with endometriosis is an important step towards understanding the pathogenesis of the disease, and the development of novel treatment and diagnostic strategies.Methods: A systematic literature search in PubMed and Embase was performed, and 118 articles were identified for further screening. Two reviewers performed article screening independently using Covidence, and 16 studies fulfilled the inclusion criteria. The Newcastle-Ottawa Scale was used to assess the quality of these studies. Results: This review presents data from eutopic endometrial biopsies from women with and without endometriosis. Several biomarkers related to a downregulated progesterone response were identified and discussed in detail.Conclusions: Our review demonstrates significant results concerning the biomarkers investigated, which may substantiate the theory of progesterone resistance in women with endometriosis. However, further research is necessary to determine their specific role and relevance.
机译：作品简介:子宫内膜异位症是一种estrogen-dependent障碍,和最近的研究表明孕激素抵抗有助于发展和病理生理学的障碍。遗传和分子的扰动子宫内膜的女性的子宫内膜异位是一种理解的重要一步疾病的发病机理和发展新奇的治疗和诊断策略。执行搜索PubMed和Embase,118篇文章被确定为进一步筛选。使用Covidence独立筛查,16岁研究满足入选标准。Newcastle-Ottawa量表是用来评估这些研究的质量。提出了数据位置正常的子宫内膜活检没有女性的子宫内膜异位症。几个相关的生物标志物表达下调孕酮是识别和响应详细讨论了。展示了重要的结果有关生物标记研究,证实理论在女性孕激素抵抗子宫内膜异位。必须确定他们的特定的角色和的相关性。

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