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首页> 外文期刊>Shock: Molecular, cellular, and systemic pathobiological aspects and therapeutic approaches = The official journal of the Shock Society, the European Shock Society, the Brazilian Shock Society, the International Federation of Shock Societies >A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock.
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A membrane-permeable radical scavenger reduces the organ injury in hemorrhagic shock.

机译：一个membrane-permeable游离基清除剂降低了在出血性休克器官损伤。

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Reactive oxygen species (ROS) contribute to the multiple organ failure (MOF) in hemorrhagic shock. Here we investigate the effects of a membrane-permeable radical scavenger (tempol) on the circulatory failure and the organ injury and dysfunction (kidney, liver, lung, intestine) associated with hemorrhagic shock in the anesthetized rat. Hemorrhage (sufficient to lower mean arterial blood pressure to 500 mmHg for 90 min) and subsequent resuscitation with shed blood resulted (within 4 h after resuscitation) in a delayed fall in blood pressure, renal and liver injury and dysfunction as well as lung and gut injury. In all organs, hemorrhage and resuscitation resulted in the nitrosylation of proteins (determined by immunohistochemistry for nitrotyrosine) suggesting the formation of peroxynitrite and/or reactive oxygen species. Treatment of rats upon resuscitation with the membrane-permeable radical scavenger tempol (30 mg/kg bolus injection followed by an infusion of 30 mg/kg/h i.v.) attenuated the delayed circulatory failure as well as the multiple organ injury and dysfunction associated with hemorrhagic shock. Thus, we propose that an enhanced formation of ROS and/or peroxynitrite importantly contributes to the MOF in hemorrhagic shock, and that membrane-permeable radical scavengers, such as tempol, may represent a novel therapeutic approach for the therapy of hemorrhagic shock.
机译：活性氧(ROS)做出贡献多器官功能衰竭(MOF)出血性冲击。membrane-permeable游离基清除剂(tempol)循环衰竭和器官损伤和功能障碍(肾、肝、肺、肠)与出血性休克麻醉大鼠。平均动脉血压为90 500毫米汞柱min)和随后的复苏与流人的血结果(复苏后4小时内)延迟血压下降,肾脏和肝脏损伤和功能障碍以及肺部和肠道受伤。复苏导致的亚硝基化作用蛋白质(由免疫组织化学硝基酪氨酸)建议的形成过氧亚硝基和/或活性氧。治疗的老鼠在复苏membrane-permeable游离基清除剂tempol (30毫克/公斤丸注入注入紧随其后30毫克/公斤/ h增长值)减毒的延迟循环衰竭以及多个器官损伤和功能障碍有关出血性休克。增强活性氧和/或过氧硝酸盐的形成重要的是会导致出血性的财政部冲击,membrane-permeable激进食腐动物,比如tempol,可能代表一个小说治疗方法的治疗出血性休克。

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