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首页> 外文期刊>Journal of cellular physiology. >The murburn precepts for cellular ionic homeostasis and electrophysiology
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The murburn precepts for cellular ionic homeostasis and electrophysiology

机译：细胞离子murburn戒律体内平衡和电生理学

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摘要

Starting from the basic molecular structure and redox properties of its components, we build a macroscopic cellular electrophysiological model. We first present a murburn purview that could explain ion distribution in bulk-milieu/membrane-interface and support the origin of trans-membrane potential (TMP) in cells. In particular, the discussion focuses on how cells achieve disparity in the distribution of monovalent and divalent cations within (K~+ >Na~+ >Mg~(2+) >Ca~(2+)) and outside (Na~+ >K~+ >Ca~(~(~(2+))) >Mg~(2+)). We explore how TMP could vary for resting/graded/action potentials generation and project a model for impulse conduction in neurons. Outcomes based on murburn bioenergetic equilibriums leading to solubilization of ion-pairs, membrane's permittivity, protein channels' fluxes, and proteins' innate ability to bind/adsorb ions selectively are projected as the integral rationale. We also provide experimental modalities to ratify the projections.
机译：从基本分子结构和开始氧化还原特性的组件,我们建立一个宏观细胞电生理模型。我们首先提出一个murburn可能的范围解释离子分布bulk-milieu / membrane-interface和支持转移膜的起源(TMP)的潜力细胞。细胞如何实现分布的差异单价和二价阳离子(K ~ +>,多达Na +,多达>毫克(2 +)>的歌词,多达(2 +)),and外出,多达(Na +,多达> K +> Ca ~(~(~(2 +))) >毫克~(2 +))。可以改变休息/等级/动作电位一代和项目模型的冲动在神经元传导。生物能量学平衡导致溶解的离子对膜的介电常数、蛋白质的通量和渠道蛋白质绑定/吸附离子的天生能力有选择地预计的积分基本原理。形式批准的预测。

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