Epigallocatechin-3-gallate stimulates StAR expression and progesterone production in human granulosa cells through the 67-kDa laminin receptor-mediated CREB signaling pathway

Lanlan Fang; Yanjie Guo; Yiran LiQiongqiong JiaXiaoyu HanBoqun LiuJiaye ChenJung-Chien ChengYing-Pu Sun

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Epigallocatechin-3-gallate stimulates StAR expression and progesterone production in human granulosa cells through the 67-kDa laminin receptor-mediated CREB signaling pathway

机译：Epigallocatechin-3-gallate刺激星表达和孕激素在人类生产通过67 kda颗粒细胞层粘连蛋白受体介导分子信号通路

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Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechins extracted from green tea. The health benefits of EGCG have been extendedly studied. Ovarian steroidogenesis plays a pivotal role in maintaining normal reproductive function. Granulosa cells in the ovary are essential for steroid hormone production. To date, the effect of EGCG on steroidogenesis in human granulosa cells remains unclear. In the present study, we examine the physiological concentrations of EGCG on steroidogenesis in a steroidogenic human granulosa-like tumor cell line, KGN. Our results demonstrate that treatment with EGCG upregulates steroidogenic acute regulatory protein (StAR) expression and increases progesterone (P4) production. EGCG does not affect the expression levels of other steroidogenesis-related enzymes, such as P450 side-chain cleavage enzyme, 3β-hydroxysteroid dehydrogenase, and aromatase. In addition, we identify the expression of 67-kDa laminin receptor (67LR) in KGN cells. Moreover, EGCG-induced StAR expression and P4 production require the 67LR-mediated activation of the PKA-CREB signaling pathway. These results provide a better understanding of the function of EGCG on ovarian steroidogenesis, which may lead to the development of alternative therapeutic approaches for reproductive disorders.

机译：Epigallocatechin-3-gallate (EGCG)是最丰富的生物活性和儿茶素从绿茶中提取。EGCG是长期研究。类固醇生成扮演关键的角色维护正常的生殖功能。在卵巢颗粒细胞是必不可少的甾类激素的生产。EGCG在类固醇生成人类的颗粒细胞仍不清楚。检查EGCG的生理浓度在人类steroidogenic类固醇生成KGN granulosa-like肿瘤细胞系。证明EGCG移植治疗steroidogenic急性监管蛋白(明星)表达和增加孕酮(P4)生产。水平的其他steroidogenesis-related酶,如P450侧链裂解酶,3β-hydroxysteroid脱氢酶和芳香化酶。此外,我们确认67 kda的表达层粘连蛋白受体(67 lr) KGN细胞。EGCG-induced明星表达和P4生产需要67 lr-mediated激活的PKA-CREB信号通路。更好的理解EGCG的功能卵巢类固醇生成,这可能会导致替代治疗方法的发展生殖障碍。

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来源
《Journal of cellular physiology.》 |2022年第1期|687-695|共9页
作者
Lanlan Fang; Yanjie Guo; Yiran LiQiongqiong JiaXiaoyu HanBoqun LiuJiaye ChenJung-Chien ChengYing-Pu Sun;
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Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First;

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正文语种英语
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epigallocatechin gallate; Granulosa Cells; Progesteronesteroid biosynthesisLaminin receptorsTumor cell lines;

机译：细胞;Progesteronesteroid biosynthesisLamininreceptorsTumor细胞系;

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Epigallocatechin-3-gallate stimulates StAR expression and progesterone production in human granulosa cells through the 67-kDa laminin receptor-mediated CREB signaling pathway

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