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首页> 外文期刊>Journal of cellular physiology. >Single-cell analyses reveal the differentiation shifts of Schwann cells in neonatal rat sciatic nerves
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Single-cell analyses reveal the differentiation shifts of Schwann cells in neonatal rat sciatic nerves

机译：单细胞分析揭示了分化雪旺细胞的变化在新生儿鼠坐骨神经

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摘要

Schwann cells provide essential physical and chemical support for neurons and play critical roles in the peripheral nervous system. To acquire an enhanced understanding of the genetic characteristics of Schwann cells, we analyzed single-cell transcriptional profiling of Schwann cells in neonatal rat sciatic nerves, ordered the pseudotemporal states of Schwann cells, and determined the magnitude of RNA velocity vectors as well as cell cycle stages of Schwann cell subtypes. We discovered the cellular heterogeneity of Schwann cells in neonatal rat sciatic nerves, revealed the dynamic changes of Schwann cell subtypes, and pointed out the differentiation trajectory from Timp3- and Col5a3-expressing Schwann cell subtype 3 to other Schwann cell subtypes. The functional interpretation further indicated that subtype 3 Schwann cells display genetic signatures of DNA replication and the acquisition of mesenchymal traits. Our study presents a transcriptional summarization of the differentiation states of Schwann cell subtypes in neonatal rat sciatic nerves at single-cell resolution and may serve as a foundation for a deeper comprehension of the involvement of Schwann cells in the development and regeneration of peripheral nerves.
机译：雪旺细胞提供基本物理化学支持神经元和发挥至关重要周围神经系统的角色。获得一个增强理解的基因雪旺细胞的特点,我们进行了分析单细胞转录分析施沃恩细胞新生大鼠坐骨神经,下令pseudotemporal雪旺细胞的状态RNA速度矢量的大小决定的以及许旺细胞的细胞周期阶段子类型。在新生鼠雪旺细胞的异质性坐骨神经,显示的动态变化许旺细胞亚型,指出了分化从Timp3和轨迹Col5a3-expressing许旺细胞亚型3许旺细胞亚型。解释进一步表明亚型3雪旺细胞显示DNA的遗传特征复制和间叶细胞的收购特征。总结的分化状态在新生鼠坐骨许旺细胞亚型神经在单细胞分辨率和可以作为更深入理解的基础雪旺细胞的参与发展和周围神经的再生。

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