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首页> 外文期刊>Journal of cellular physiology. >Lipocalin 2 increases after high-intensity exercise in humans and influences muscle gene expression and differentiation in mice
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Lipocalin 2 increases after high-intensity exercise in humans and influences muscle gene expression and differentiation in mice

机译：Lipocalin 2后高强度增加锻炼肌肉基因在人类和影响在老鼠身上表达和分化

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摘要

Lipocalin 2 (LCN2) is an adipokine that accomplishes several functions in diverse organs. However, its importance in muscle and physical exercise is currently unknown. We observed that following acute high-intensity exercise ("Gran Sasso d'Italia" vertical run), LCN2 serum levels were increased. The Wnt pathway antagonist, DKK1, was also increased after the run, positively correlating with LCN2, and the same was found for the cytokine Interleukin 6. We, therefore, investigated the involvement of LCN2 in muscle physiology employing an Lcn2 global knockout (Lcn2~(-/-) ) mouse model. Lcn2~(-/-) mice presented with smaller muscle fibres but normal muscle performance (grip strength metre) and muscle weight. At variance with wild type (WT) mice, the inflammatory cytokine Interleukin 6 was undetectable in Lcn2~(-/-) mice at all ages. Intriguingly, Lcn2~(-/-) mice did not lose gastrocnemius and quadriceps muscle mass and muscle performance following hindlimb suspension, while at variance with WT, they lose soleus muscle mass. In vitro, LCN2 treatment reduced the myogenic differentiation of C2C12 and primary mouse myoblasts and influenced their gene expression. Treating myoblasts with LCN2 reduced myogen-esis, suggesting that LCN2 may negatively affect muscle physiology when upregu-lated following high-intensity exercise.
机译：Lipocalin 2 (LCN2)是一种adipokine完成了几个函数在不同器官。然而,它的重要性在肌肉和身体运动是目前未知。急性高强度运动后(“格兰萨索环意大利自行车赛”“垂直运行),LCN2血清水平是增加了。也增加了运行后,积极吗与LCN2关联,发现了相同的细胞因子白介素6。调查了LCN2参与肌肉生理学用人Lcn2全球淘汰赛(Lcn2 ~(- / -)小鼠模型。面对小肌肉纤维但正常肌肉(握力米)和性能肌肉重量。老鼠,炎性细胞因子白介素6检测不到Lcn2 ~(- / -)小鼠年龄。有趣的是,Lcn2 ~(- / -)小鼠并没有输腓肠肌和股四头肌肌肉肌肉性能下肢后悬架,在方差与WT,他们失去比目鱼肌肌肉质量。肌原性的C2C12分化和初选小鼠成肌细胞和影响他们的基因表达式。myogen-esis,表明LCN2可能负面当upregu-lated影响肌肉生理学高强度运动后。

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