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首页> 外文期刊>Journal of cellular physiology. >Critical analysis of explanations for cellular homeostasis and electrophysiology from murburn perspective
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Critical analysis of explanations for cellular homeostasis and electrophysiology from murburn perspective

机译：细胞的关键分析解释从murburn体内平衡和电生理学的角度来看

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摘要

Pursuits in modern cellular electrophysiology are fraught with disagreements at a fundamental level. While the membrane theory of homeostasis deems the cell membrane and proteins embedded therein as the chief players, the association-induction (or sorption/bulk-phase) hypothesis considers the aqueous phase of dissolved proteins (cytoplasm/protoplasm) as the key determinant of cellular composition and ionic fluxes. In the first school of thought, trans-membrane potential (TMP) and selective ion pumps/channels are deemed as key operative principles. In the latter theory, sorption-desorption dynamics and rearrangements of bulk phase determine the outcomes. In both these schools of thought, theorists believe that the macroscopic phase electroneutrality holds, TMP (whether in resting or in activated state) results solely due to ionic concentration differentials across the membrane, and the concerned proteins undergo major conformation changes to affect/effect the noted outcomes. The new entry into the field, murburn concept, builds starting from molecular considerations to macroscopic observations. It moots "effective charge separation" and intricate "molecule-ion-radical" electron transfer equilibriums as a rationale for ionic concentration differentials and TMP variation. After making an unbiased appraisal of the two classical schools of thought, the review makes a point-wise analysis of some hitherto unresolved observations/considerations and suggests the need to rethink the mechanistic perspectives.
机译：在现代细胞电生理学是追求充满了根本的分歧的水平。认为嵌入细胞膜和蛋白质其中的主要球员,association-induction(或吸附/体相)假说认为的水相溶解蛋白质(细胞质/原生质)细胞成分和离子的关键决定因素通量。转移膜电位(TMP)和选择性离子泵/渠道视为重要的手术的原则。sorption-desorption动力学和重组体相的确定结果。这些学派理论家相信宏观电中性持有阶段,TMP(无论是在休息或激活状态)结果完全是因为离子浓度差异在膜,有关蛋白质进行主要构象指出结果变化影响/影响。新进入领域,murburn概念,构建从分子方面的考虑宏观的观测。电荷分离”和复杂的“molecule-ion-radical”电子转移平衡离子的理由浓度差异和TMP变异。后做一个公正的评价古典学派,审查了逐点分析一些至今还未得到解决观察/注意事项和建议的必要性重新考虑机械的观点。

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