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首页> 外文期刊>Journal of cellular physiology. >Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets
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Metastasis associated long noncoding RNAs in glioblastoma: Biomarkers and therapeutic targets

机译：转移相关的长非编码rna胶质母细胞瘤:生物标志物和治疗目标

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摘要

Glioblastoma (GBM) is the most aggressive, malignant, and therapeutically challenging Grade IV tumor of the brain. Although the possibility of distant metastasis is extremely rare, GBM is known to cause intracranial metastasis forming aggressive secondary lesions resulting in a dismal prognosis. Metastasis also plays an important role in tumor dissemination and recurrence making GBM largely incurable. Recent studies have indicated the importance of long noncoding RNAs (lncRNAs) in GBM metastasis. lncRNAs are a class of regulatory noncoding RNAs (>200 nt) that interact with DNA, RNA, and proteins to regulate various biological processes. This is the first comprehensive review summarizing the lncRNAs associated with GBM metastasis and the underlying molecular mechanism involved in migration/invasion. We also highlight the complex network of lncRNA/miRNA/protein that collaborate/compete to regulate metastasis-associated genes. Many of these lncRNAs also show attractive potential as diagnostic/prognostic biomarkers. Finally, we discuss various therapeutic strategies and potential applications of lncRNAs as therapeutic targets for the treatment of GBM.
机译：胶质母细胞瘤(GBM)是最积极,恶性肿瘤,治疗具有挑战性的年级大脑的静脉瘤。远处转移是非常罕见的,“绿带运动”导致颅内转移形成积极的继发性病变导致惨淡的预后。在肿瘤传播和重要的作用复发GBM很大程度上是无法治愈的。研究表明长时间的重要性非编码rna (lncRNAs)“绿带运动”转移。lncRNAs监管非编码rna是一类(> 200元)与DNA, RNA,和蛋白质调节各种各样的生物流程。总结了lncRNAs与“绿带运动”联系在一起转移和潜在的分子机制参与迁移/入侵。lncRNA / microrna /蛋白质的复杂网络合作/监管竞争转移相关的基因。lncRNAs也显示有吸引力的潜力诊断/预测生物标志物。不同的治疗策略和讨论lncRNAs作为治疗的潜在应用“绿带运动”的治疗目标。

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