...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review
【24h】

Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review

机译：扰流对细胞的影响变化表明血管动脉瘤起始,扩张和破裂:病理方法回顾

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aneurysms are malformations within the arterial vasculature brought on by the structural breakdown of the microarchitecture of the vessel wall, with aneurysms posing serious health risks in the event of their rupture. Blood flow within vessels is generally laminar with high, unidirectional wall shear stressors that modulate vascular endothelial cell functionality and regulate vascular smooth muscle cells. However, altered vascular geometry induced by bifurcations, significant curvature, stenosis, or clinical interventions can alter the flow, generating low stressor disturbed flow patterns. Disturbed flow is associated with altered cellular morphology, upregulated expression of proteins modulating inflammation, decreased regulation of vascular permeability, degraded extracellular matrix, and heightened cellular apoptosis. The understanding of the effects disturbed flow has on the cellular cascades which initiate aneurysms and promote their subsequent growth can further elucidate the nature of this complex pathology. This review summarizes the current knowledge about the disturbed flow and its relation to aneurysm pathology, the methods used to investigate these relations, as well as how such knowledge has impacted clinical treatment methodologies. This information can contribute to the understanding of the development, growth, and rupture of aneurysms and help develop novel research and aneurysmal treatment techniques.
机译：在动脉动脉瘤是畸形脉管系统带来的结构性的破裂的微体系结构墙,动脉瘤造成严重的健康风险在发生破裂。船舶通常高的层状,单向墙剪切压力调节血管内皮细胞功能和调节血管平滑肌细胞。改变引起的血管几何分岔,重要的曲率、狭窄或临床干预措施可以改变流,生成低压力扰动流模式。扰流与改变有关细胞形态、调节的表达蛋白质调节炎症,降低了调节血管渗透性,退化细胞外基质和细胞加剧细胞凋亡。扰流的细胞级联启动动脉瘤和促进他们的后续增长的本质可以进一步阐明这一点复杂的病理。电流扰动流和知识它与动脉瘤病理关系的方法用来研究这些关系,以及这样的知识是如何影响临床吗治疗方法。导致的理解开发、发展和破裂的动脉瘤帮助开发小说研究和动脉瘤性治疗技术。

著录项

相似文献

  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号