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首页> 外文期刊>Journal of cellular physiology. >The 'Dark Side' of autophagy on the maintenance of genome stability: Does it really exist during excessive activation?
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The 'Dark Side' of autophagy on the maintenance of genome stability: Does it really exist during excessive activation?

机译：自噬的“阴暗面”的维护在基因组稳定性:它真的存在过度激活吗?

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摘要

Dysregulation of DNA damage response/repair and genomic instability promote tumor-igenesis and the development of various neurological diseases. Autophagy is a dynamic catabolic process used for removing unnecessary or dysfunctional proteins and organelles in cells. Despite the consensus in the field that upregulation of autophagy promotes the initiation of the DNA damage response and assists the process of homologous recombination upon genotoxic stress, a few studies showed that upregulation of autophagy (or excessive autophagy), under certain circumstances, triggers caspase/apoptosis-independent DNA damage and promotes genomic instability in cells. As the cytopro-tective and the DNA repairing roles of autophagy have been discussed extensively in different reviews, here, we mainly focus on describing the latest studies which reported the "opposite" roles of autophagy (or excessive autophagy). We will discuss whether the "dark side" (i.e., the opposite/unconventional effect) of autophagy on the maintenance of DNA integrity and genomic stability really does exist in cells and if it does, will it be one of the yet-to-be-identified causes of cancer, in this review.
机译：失调的/修复和DNA损伤反应促进tumor-igenesis和基因组不稳定各种神经系统疾病的发展。自噬是一个动态的分解过程删除不必要的或不正常的蛋白质和细胞内细胞器。自噬促进的领域upregulationDNA损伤反应的起始协助同源重组的过程在基因毒性压力,一些研究表明,upregulation自噬(或过度自噬),在某些情况下,触发器半胱天冬酶/ apoptosis-independent DNA损伤促进细胞内基因组不稳定性。cytopro-tective和DNA修复的作用自噬是广泛的讨论不同的评论,在这里,我们主要关注描述最新的研究报道“相反”的角色自噬(或过度自噬)。面”(也就是说,相反/非常规的效果)自噬的DNA完整性的维护并在细胞基因组稳定性确实存在如果是这样,将是其中的一个尚未查明原因的癌症审查。

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