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首页> 外文期刊>Journal of cellular physiology. >Lnc‐CPLC promotes the progression of colorectal cancer via regulating ZBTB34 by competitively binding miR‐4319
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Lnc‐CPLC promotes the progression of colorectal cancer via regulating ZBTB34 by competitively binding miR‐4319

机译：信号量CPLC促进大肠癌的进展通过调节癌症ZBTB34竞争力绑定miR量4319

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摘要

Abstract Long noncoding RNAs (lncRNAs) have been considered as regulatory molecules that play crucial roles in diverse biological processes, including the regulation of tumor progression. However, in colorectal cancer (CRC), due to the complex regulatory relationships involved in lncRNAs, the details of the specific mechanism still need to be elucidated. To discover the key regulatory role of lncRNA in CRC, we used bioinformatics analysis methods for preliminary screening. Through the combination of in vitro and in vivo verification, we further comprehensively analyzed the specific regulation of the key gene and the related key lncRNA in CRC. We found that ZBTB34 and lnc‐CPLC (CRC progression‐associated lncRNA)?had a strong correlation, which plays a key role in the regulation of CRC. Furthermore, by exerting the “sponge” function, lnc‐CPLC could bind to miR4319 and release its binding to the 3'UTR of ZBTB34 mRNA. Our results reveal the mechanism of the lnc‐CPLC/miR‐4319/ZBTB34 signal axis in CRC and provide evidence for elucidating the complex molecular mechanisms in tumors.
机译：摘要长非编码rna (lncRNAs)视为监管分子至关重要的角色在不同的生物过程,包括肿瘤恶化的规定。然而,在结直肠癌(CRC),由于参与复杂的监管的关系lncRNAs,细节的具体机制仍然需要阐明。监管职责的lncRNA CRC,我们使用初步的生物信息学分析方法筛选。和体内验证,我们进一步全面分析了具体的规定的关键基因和相关关键lncRNACRC。发展特色相关lncRNA) ?中起着关键作用的相关性儿童权利公约的规定。“海绵”函数,信号量CPLC可以绑定到miR4319并释放其绑定3 'utr ZBTB34信使rna。信号量CPLC /米尔轴在CRC和公/ 4319 / ZBTB34信号为阐明复杂的提供证据肿瘤的分子机制。

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