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首页> 外文期刊>Journal of cellular physiology. >The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development
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The emerging roles of the interaction between m6A modification and c‐Myc in driving tumorigenesis and development

机译：的新兴角色m6A之间的互动修改和c Myc在推动肿瘤发生和发展

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Abstract N6‐methyladenosine (m6A) is an extremely common and conservative posttranscriptional modification, that can specifically target and regulate the expression or stability of a series of tumor‐related genes, thus playing critical roles in the occurrence and development of tumors. c‐Myc is an important tumorigenic transcription factor that promotes tumorigenesis and development by mainly regulating the expression of downstream target genes. Increasing evidence shows that m6A modification, as well as abnormal expression and regulation of c‐Myc, is critical molecular mechanisms driving tumorigenesis and development. Although more evidence has been uncovered about the individual roles of m6A modification or c‐Myc in tumors, the interaction between m6A modification and c‐Myc in tumorigenesis and development has not been systematically summarized. Therefore, this review is focused on the mutual regulation between m6A modification and c‐Myc expression and stability as well as its roles in tumorigenesis and development. We also summarized the potential value of the interaction between m6A modification and m6A expression and stability in tumor diagnosis and treatment, which provides a specific reference for revealing the mechanism of tumor occurrence and development as well as clinical diagnosis and treatment.
机译：文摘N6 methyladenosine应承担(m6A)是一个极其常见的和保守的转录后的修改,可以明确目标和调节一系列的表达式或稳定肿瘤检测相关基因,从而扮演至关重要角色的发生和发展肿瘤。转录因子促进肿瘤发生和发展的主要规范下游靶基因的表达。证据表明,m6A修改,以及c Myc应承担的异常表达与调控关键的分子机制驱动肿瘤发生和发展。对单个证据被发现角色m6A修改或者c Myc在肿瘤互动m6A修改和c Myc在肿瘤发生和发展没有系统地总结了。重点是m6A之间的相互调节修改和c Myc基因表达和稳定以及其在肿瘤发生中的作用发展。值之间的交互m6A修改在肿瘤和m6A表达与稳定诊断和治疗,它提供了一个具体参考揭示的机制以及肿瘤发生和发展临床诊断和治疗。

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