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首页> 外文期刊>Journal of cellular physiology. >Identification of novel genes in testicular cancer microenvironment based on ESTIMATE algorithm-derived immune scores
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Identification of novel genes in testicular cancer microenvironment based on ESTIMATE algorithm-derived immune scores

机译：小说在睾丸癌基因的识别基于估计的微环境算法的免疫分数

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摘要

Testicular cancer is the most common solid malignancy among young men. We downloaded data of testicular cancer patients from The Cancer Genome Atlas database to find novel genes in the testicular cancer microenviroment based on ESTIMATE algorithm-derived immune scores. A total of 156 cases of testicular cancer were included in this study and 165 cases of normal testicular tissues were used. We divided the testicular cancer patients into high- and low-score groups based on their immune scores. We identified 1,226 differentially expressed genes (fold change > 2, false discovery rate < 0.05), including 688 downregulated genes and 538 upregulated genes, between these two groups. The top Gene Ontology terms were involved in the immune response-regulating cell surface receptor signaling pathway, immune response-activating cell surface receptor signaling pathway, external side of the plasma membrane, and receptor ligand activity. By performing the Kyoto Encyclopedia of Genes and Genomes analysis, we demonstrated that cAMP signaling pathway was highly enriched among these differentially expressed genes. High expression of LINC01564, LINC02208, ODAM, RNA5SP111, and RNU6-196P were found to be associated with poor overall survival. The expression of genes was further validated by the Human Protein Atlas and only ALB and IFNG were demonstrated to be differentially expressed between testis tissue and testicular cancer tissue.
机译：睾丸癌是最常见的固体恶性肿瘤在年轻男性。癌症基因组的睾丸癌患者地图集数据库发现小说中的基因睾丸癌microenviroment基于估计算法免疫分数。包括156例睾丸癌在这项研究中,165例正常睾丸组织使用。癌症患者分为高——和低分组基于免疫的分数。差异表达基因(褶皱变化> 2,错误发现率< 0.05),其中包括688538年表达下调基因和调节基因,这两组之间。参与免疫response-regulating细胞表面受体信号通路,免疫response-activating细胞表面受体信号通路、外部一边的质膜和受体配体活动。基因和基因组分析,我们证明了阵营之间的信号通路是高纯度这些差异表达的基因。表达LINC01564、LINC02208 ODAM,RNA5SP111, rnu6 - 196 p被发现总体存活率较差有关。进一步验证了基因的表达人类蛋白质图谱,只有铝青铜和IFNG证明了差异表达睾丸组织和睾丸癌之间的关系组织。

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