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首页> 外文期刊>Journal of cellular physiology. >Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats
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Hydroxytyrosol modifies skeletal muscle GLUT4/AKT/Rac1 axis in trained rats

机译：Hydroxytyrosol修改骨骼肌GLUT4 / AKT Rac1轴训练老鼠

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摘要

Training induces a number of healthy effects including a rise in skeletal muscle (SKM) glucose uptake. These adaptations are at least in part due to the reactive oxygen species produced within SKM, which is in agreement with the notion that antioxidant supplementation blunts some training-induced adaptations. Here, we tested whether hydroxytyrosol (HT), the main polyphenol of olive oil, would modify the molecular regulators of glucose uptake when HT is supplemented during exercise. Rats were included into sedentary and exercised (EXE) groups. EXE group was further divided into a group consuming a low HT dose (0.31 mg●kg●d; EXElow), a moderate HT dose (4.61 mg●kg●d; EXEmid), and a control group (EXE). EXE raised glucose transporter type 4 (GLUT4) protein content, Ras-related C3 botulinum toxin substrate 1 (Rac1) activity, and protein kinase b (AKT) phosphorylation in SKM. Furthermore, EXElow blunted GLUT4 protein content and AKT phosphorylation while EXEmid showed a downregulation of the GLUT4/AKT/Rac1 axis. Hence, a low-to-moderate dose of HT, when it is supplemented as an isolated compound, might alter the beneficial effect of training on basal AKT phosphorylation and Racl activity in rats.
机译：培训引发许多健康的影响包括增加骨骼肌葡萄糖(日)吸收。由于产生的活性氧在日,同意这一概念,抗氧化剂补充减弱一些training-induced改编。是否hydroxytyrosol (HT),主要多酚橄榄油,将修改分子监管者HT时葡萄糖吸收的在运动中补充。久坐不动和行使(EXE)组。组进一步划分为一组消费●HT低剂量(0.31毫克公斤●d;●HT剂量(4.61毫克公斤●d;组(EXE)。4 (GLUT4)蛋白质含量,Ras-related C3肉毒杆菌毒素基质1 (Rac1)活动,蛋白激酶b(一种蛋白激酶)磷酸化在日。此外,EXElow钝化GLUT4蛋白含量和一种蛋白激酶磷酸化而EXEmid显示downregulation GLUT4的/ AKT Rac1轴。低剂量的HT,当它补充作为一个孤立的化合物,可能会改变培训基底AKT的有益作用磷酸化和射氯活动的老鼠。

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