...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Effect of angiotensin II and angiotensin-(1-7) on proliferation of stem cells from human dental apical papilla
【24h】

Effect of angiotensin II and angiotensin-(1-7) on proliferation of stem cells from human dental apical papilla

机译：血管紧张素ⅱ的影响和血管紧张素- (1 - 7)人类牙齿干细胞的增殖顶端乳头

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The effects of the renin-angiotensin system (RAS) on stem cells isolated from human dental apical papilla (SCAPs) are completely unknown. Therefore, the aim of this study was to identify RAS components expressed in SCAPs and the effects of angiotensin (Ang) II and Ang-(1-7) on cell proliferation. SCAPs were collected from third molar teeth of adolescents and maintained in cell culture. Messenger RNA expression and protein levels of angiotensin-converting enzyme (ACE), ACE2, and Mas, Ang II type I (AT1) and type II (AT2) receptors were detected in SCAPs. Treatment with either Ang II or Ang-(1-7) increased the proliferation of SCAPs. These effects were inhibited by PD123319, an AT2 antagonist. While Ang II augmented mTOR phosphorylation, Ang-(1-7) induced ERK1/2 phosphorylation. In conclusion, SCAPs produce the main RAS components and both Ang II and Ang-(1-7) treatments induced cell proliferation mediated by AT2 activation through different intracellular mechanisms.
机译：肾素-血管紧张素系统(RAS)的影响干细胞与人类牙齿顶端乳头(scap)是完全未知的。因此,本研究的目的是为了识别RAS组件scap表达和影响血管紧张素II (Ang)和Ang -(1 - 7)细胞扩散。磨牙的青少年和保持细胞文化。血管紧张素转换酶(ACE)的水平,ACE2, Mas AngⅱI型和II型(AT1)(at₂)受体在scap检测。Angⅱ或Ang -(1 - 7)增加了scap扩散。抑制由PD123319 at₂拮抗剂。诱导ERK1/2磷酸化。scap产生主要的RAS组件和两种Angⅱ和Ang -(1 - 7)治疗诱导细胞扩散通过at₂激活介导的不同的细胞内机制。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号