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首页> 外文期刊>Journal of cellular physiology. >Role of iron and iron-related proteins in mesenchymal stem cells: Cellular and clinical aspects
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Role of iron and iron-related proteins in mesenchymal stem cells: Cellular and clinical aspects

机译：铁和iron-related蛋白质的作用间充质干细胞:细胞和临床方面

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摘要

Mesenchymal stem cells (MSCs) are located in various tissues where these cells show niche-dependent multilineage differentiation and secrete immunomodulatory molecules to support numerous physiological processes. Due to their regenerative and reparative properties, MSCs are extremely valuable for cell-based therapy in tackling several pathological conditions including COVID-19. Iron is essential for MSC processes but iron-loading, which is common in several chronic conditions, hinders normal MSC functionality. This not only aggravates disease pathology but can also affect allogeneic and autologous MSC therapy. Thus, understanding MSCs from an iron perspective is of clinical significance. Accordingly, this review highlights the roles of iron and iron-related proteins in MSC physiology. It describes the contribution of iron and endogenous iron-related effectors like hepcidin, ferro-portin, transferrin receptor, lactoferrin, lipocalin-2, bone morphogenetic proteins and hypoxia inducible factors in MSC biology. It summarises the excess-iron-induced alterations in MSC components, processes and discusses signalling pathways involving ROS, PI3K/AKT, MAPK, p53, AMPK/MFF/DRP1 and Wnt. Additionally, it evaluates the endogenous and exogenous saviours of MSCs against iron-toxicity. Lastly, it elaborates on the involvement of MSCs in the pathology of clinical conditions of iron-excess, namely, hereditary hemochromatosis, diabetes, β-thalassaemia and myelodysplastic syndromes. This unique review integrates the distinct fields of iron regulation and MSC physiology. Through an iron-perspective, it describes both mechanistic and clinical aspects of MSCs and proposes an iron-linked MSC-contribution to physiology, pathology and therapeutics. It advances the understanding of MSC biology and may aid in identifying signalling pathways, molecular targets and compounds for formulating adjunctive iron-based therapies for excess-iron conditions, and thereby inform regenerative medicine.
机译：间充质干细胞(msc)位于各种组织这些细胞niche-dependent multilineage分化和分泌免疫调节分子的支持许多生理过程。再生和修复性能,msc极其有价值的细胞疗法解决一些病理条件包括COVID-19。过程但iron-loading,这是常见的一些慢性疾病,阻碍正常的MSC功能。病理但也能影响同种异体和自体MSC治疗。从铁的角度来看是临床的意义。铁和iron-related蛋白质的角色MSC生理机能。铁和内源性iron-related效应器hepcidin ferro-portin,转铁蛋白受体,乳铁蛋白、lipocalin-2骨形成蛋白质和缺氧诱导因子在MSC生物学。改变MSC组件、过程和讨论了涉及ROS信号通路,PI3K / AKT、MAPK p53, AMPK / MFF / DRP1和Wnt。此外,内生和评估外生msc对iron-toxicity的救星。最后,本文将详细阐述msc的参与病理学的临床条件iron-excess,即遗传性血色素沉着症,糖尿病、β地中海贫血、骨髓增生异常综合症。不同领域的铁监管和MSC生理机能。描述了机械和临床两方面msc和提出了一个铁蛋白MSC-contribution生理学、病理学和疗法。MSC生物学和可能有助于识别信号途径,和化合物分子的目标制定辅助铁基治疗过多的铁条件,从而通知再生医学。

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