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首页> 外文期刊>Journal of cellular physiology. >Glycine suppresses kidney calcium oxalate crystal depositions via regulating urinary excretions of oxalate and citrate
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Glycine suppresses kidney calcium oxalate crystal depositions via regulating urinary excretions of oxalate and citrate

机译：甘氨酸抑制肾草酸钙晶体通过调节尿排泄物的口供草酸、柠檬酸

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摘要

An abnormal urine composition is a key reason for kidney stone formation, but little is known about the roles of small metabolites in the urine during kidney stone formation. Here, we found urine glycine in patients with kidney calcium oxalate (CaOx) stone was significantly lower than that in healthy people via ~1H NMR spectra detection, and investigated the role and underlying mechanism of glycine in the regulation of CaOx stone formation. Our results showed that glycine could significantly attenuate ethylene glycol-induced CaOx crystal depositions in rat kidney via decreasing urine oxalate and increasing urine citrate. Mechanism studies revealed that glycine could decrease urine oxalate through downregulating Slc26a6 expression, whereas increase urine citrate via inhibiting Nadc1 expression. Moreover, glycine decreased the protein expression of both Slc26a6 and Nadc1 via increasing the expression of miRNA-411-3p, which directly bound to the 3'-untranslated regions of Slc26a6 and Nadc1 messenger RNAs, in vitro and in vivo. Together, our results revealed a novel role of glycine in the regulation of kidney CaOx crystal formation and provided a potential target for the treatment of kidney CaOx stone.
机译：异常尿液成分是一个关键原因肾结石的形成,但很少被人所知小的尿液中代谢物的角色在肾结石的形成。肾脏患者尿甘氨酸钙草酸(草酸钙)明显低于在健康的人通过~ 1 h NMR谱检测和调查和扮演的角色甘氨酸的底层机制的监管草酸钙结石的形成。甘氨酸可以显著减弱乙烯在鼠glycol-induced草酸钙晶体口供通过减少尿液草酸和肾脏增加尿柠檬酸。透露,甘氨酸可以减少尿草酸通过下调Slc26a6表达,而增加尿柠檬酸通过抑制Nadc1表达式。Slc26a6的蛋白表达减少并通过增加Nadc1的表达microrna - 411 - 3 - p,直接绑定到3 '非翻译区Slc26a6 Nadc1信使rna,在体外和体内。我们的研究结果揭示了小说中甘氨酸的作用肾草酸钙晶体形成的监管并提供了一个潜在的治疗目标肾草酸钙石。

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