...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >circHIPK3 regulates proliferation and differentiation of myoblast through the miR-7/TCF12 pathway
【24h】

circHIPK3 regulates proliferation and differentiation of myoblast through the miR-7/TCF12 pathway

机译：circHIPK3调节增殖和成肌细胞的分化miR-7 / TCF12通路

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Skeletal muscle development is a complex biological process involving multiple key genes, signaling pathways and noncoding RNAs, including microRNAs and circular RNAs (circRNAs). However, the regulatory relationship among them is so complicated that it has not yet been fully elucidated. In this study, we found that miR-7 inhibited C2C12 cell proliferation and differentiation by targeting transcription factor 12 (TCF12). circHIPK3 acted as a competing endogenous RNA, and its overexpression effectively reversed the regulation of miR-7 on C2C12 cell proliferation and differentiation by increasing TCF12 expression. Taken together, our findings provide evidence that circHIPK3 regulates skeletal muscle development through the miR-7/TCF12 pathway. This study provides a scientific basis for further research on skeletal muscle development at the circRNA level.
机译：骨骼肌是一个复杂的发展生物过程涉及多个关键基因,信号通路和非编码rna,包括小分子核糖核酸和圆形rna (circRNAs)。它们之间的管理关系复杂,尚未完全阐明。抑制C2C12细胞增殖差异化的目标转录因子12 (TCF12)。内源性RNA,它的超表达有效地逆转miR-7的规定C2C12细胞增殖和分化增加TCF12表达式。研究结果提供证据表明circHIPK3通过调节骨骼肌发展miR-7 / TCF12通路。科学依据对骨骼的进一步研究circRNA肌肉发展水平。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号