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首页> 外文期刊>Journal of cellular physiology. >Neuroinf lammation: The next target of exosomal microRNAs derived from mesenchymal stem cells in the context of neurological disorders
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Neuroinf lammation: The next target of exosomal microRNAs derived from mesenchymal stem cells in the context of neurological disorders

机译：Neuroinf lammation: exosomal的下一个目标小分子核糖核酸来源于间充质干细胞神经紊乱的环境中

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摘要

Among different types of mechanisms involved in neurological disorders, neuroin-flammation links initial insults to secondary injuries and triggers some chronic outcomes, for example, neurodegenerative disorders. Thus, anti-inflammatory substances can be targeted as a novel therapeutic option for translational and clinical research to improve brain disease outcomes. In this review, we propose to introduce a new insight into the anti-inflammatory effects of mesenchymal stem cells (MSCs) as the most frequent source for stem cell therapy in neurological diseases. Our insight incorporates a bystander effect of these stem cells in modulating inflammation and microglia/macrophage polarization through exosomes. Exosomes are nano-sized membrane vesicles that carry cell-specific constituents, including protein, lipid, DNA, and RNA. microRNAs (miRNAs) have recently been detected in exosomes that can be taken up by other cells and affect the behavior of recipient cells. In this article, we outline and highlight the potential use of exosomal miRNAs derived from MSCs for inflammatory pathways in the context of neurological disorders. Furthermore, we suggest that focusing on exosomal miRNAs derived from MSCs in the course of neuroinflammatory pathways in the future could reveal their functions for diverse neurological diseases, including brain injuries and neurodegenerative diseases. It is hoped that this study will contribute to a deep understanding of stem cell bystander effects through exosomal miRNAs.
机译：在不同类型的机制神经紊乱,neuroin-flammation链接最初的二次伤害和侮辱引发一些慢性的结果,例如,神经退行性疾病。抗炎物质可以作为目标平移和新颖的治疗选择改善大脑疾病的临床研究结果。抗炎作用的新的见解间充质干细胞(msc)为最频繁的来源的干细胞疗法神经系统疾病。这些干细胞的旁观者效应调节炎症和小胶质细胞/巨噬细胞极化液。纳米级膜小泡携带特异性成分,包括蛋白质、脂肪、DNA和RNA。最近在液,可以被发现被其他细胞和影响行为受体细胞。和突出exosomal的潜在用途炎症的microrna源自msc通路的神经障碍。在exosomal microrna源自msc神经炎症通路的课程未来可以揭示其功能多样化神经系统疾病,包括脑损伤和神经退行性疾病。本研究将有助于深度了解干细胞的旁观者效应通过exosomal microrna。

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