...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cellular physiology. >Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome
【24h】

Pathophysiological roles of chronic low-grade inflammation mediators in polycystic ovary syndrome

机译：慢性低度的病理生理作用炎症介质在多囊卵巢并发症状

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in reproductive-aged women. Its basic characteristics are ovulatory dysfunction and ovarian overproduction of androgens that lead to severe symptoms such as insulin resistance, hirsutism, infertility, and acne. Notwithstanding the disease burden, its underlying mechanisms remain unknown, and no causal therapeutic exists. In recent years, further studies showed that inflammation processes are involved in ovulation and play a key role in ovarian follicular dynamics. Visceral adipose tissue can cause inflammatory response and maintenance of the inflammation state in adipocytes by augmented production of inflammatory cytokines, monocyte chemoattractant proteins, and recruitment of the immune cell. Therefore, the PCOS can be related to a low-grade inflammation state and inflammatory markers. Investigating the inflammatory processes and mediators that contribute to the commencement and development of PCOS can be a critical step for better understanding the patho-physiology of the disease and its treatment through inhibition or control of related pathways. In the present review, we discuss the pathophysiological roles of chronic low-grade inflammation mediators including inflammasome-related cytokines, interleukin-1beta (IL-1beta), and IL-18 in PCOS development.
机译：多囊卵巢综合征(PCOS)是最常见的荷尔蒙失调疾病生殖期的女性。是排卵的功能障碍和特征卵巢雄激素导致生产过剩严重的症状,如胰岛素抵抗,多毛症、不孕和粉刺。疾病负担,其潜在的机制尚不知晓,不存在因果的治疗。近年来,进一步的研究表明,炎症过程参与排卵并在卵巢卵泡中发挥关键作用动力学。炎症反应和维护的在脂肪细胞炎症状态增广炎性细胞因子、单核细胞蛋白质化学引诱物,招聘的免疫细胞。慢性炎症状态和炎症标记物。炎症过程和介质为的开始和发展作出贡献PCOS可能是一个更好的关键一步了解疾病的patho-physiology通过抑制或控制及其治疗相关的通路。讨论慢性的病理生理作用慢性炎症介质包括inflammasome-related细胞因子,interleukin-1beta(IL-1beta),地震在PCOS的发展。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号