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首页> 外文期刊>Journal of cellular physiology. >Asmallnucleolar RNA,SNORD126, promotes adipogenesis in cells and rats by activating the PI3K-AKT pathway
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Asmallnucleolar RNA,SNORD126, promotes adipogenesis in cells and rats by activating the PI3K-AKT pathway

机译：Asmallnucleolar RNA, SNORD126,促进在细胞和大鼠通过激活脂肪形成

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摘要

Small nucleolar RNA (snoRNA) plays important role in various histogenesis. Whether snoRNA plays a role in adipogenesis is unknown. SNORD126 is a C/D box snoRNA. We previously demonstrated that SNORD126 promoted hepatocellular carcinoma cell growth by activating the phosphoinositide 3-kinase-protein kinase B (Akt) pathway through upregulating fibroblast growth factor receptor 2 expression. In the present study, we found that the expression of SNORD126 was down-regulated in the obesity-related tissues in high-fat diet-fed rats. Overexpression of SNORD126 in 3T3-L1 cells promoted adipocytes differentiation. SNORD126 significantly increased the expression of CCAAT/enhancer-binding protein α, fatty acid-binding protein 4, peroxisome proliferative-activated receptor-y, and the phosphorylation of Akt and p70S6K. Overexpression of SNORD126 in human adipose-derived stem cells stimulated adipogenesis and increased phosphorylation of Akt. Meanwhile, SNORD126 increased the messenger RNA and protein levels of cyclin D1 and cyclin-dependent kinase 2, which promoted mitotic clonal expansion progression during the early stage of 3T3-L1 cell differentiation. We further found that SNORD126 accelerated the growth of the groin fat pad and increased phosphorylation of Akt and p70S6K in rats. Overall, our results suggested that SNORD126 promoted adipocyte differentiation through increasing phosphorylation of Akt and p70S6K both in vitro and in vivo.
机译：小核仁的RNA (snoRNA)扮演重要的角色在不同的组织发生。在脂肪生成作用不明。snoRNA C / D框。SNORD126促进肝癌细胞增长通过激活磷酸肌醇3-kinase-protein激酶B(一种蛋白激酶)的途径移植纤维母细胞生长因子受体2表达式。SNORD126的表达被抑制在高脂肪饮食与肥胖相关的组织老鼠。促进脂肪细胞分化。显著增加的表达CCAAT / enhancer-binding蛋白α,脂肪结合蛋白4、过氧物酶体proliferative-activated receptor-y,一种蛋白激酶的磷酸化和p70S6K。在人类脂肪干细胞SNORD126刺激脂肪形成和增加一种蛋白激酶的磷酸化。的信使RNA和蛋白质含量增加细胞周期蛋白D1和细胞周期蛋白依赖性激酶2,促进有丝分裂克隆扩张发展在早期阶段3 t3-l1细胞分化。加速增长的腹股沟脂肪垫一种蛋白激酶的磷酸化和p70S6K增加老鼠。SNORD126促进脂肪细胞的分化通过增加一种蛋白激酶和磷酸化p70S6K体外和体内。

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