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首页> 外文期刊>Journal of cellular physiology. >Proteomic analysis of aqueous humor from cataract patients with retinitis pigmentosa
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Proteomic analysis of aqueous humor from cataract patients with retinitis pigmentosa

机译：白内障的房水蛋白质组学分析患有色素性视网膜炎

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摘要

A postcataract surgery complication in patients with retinitis pigmentosa (RP) is lens capsular contraction. To identify potential proteins contributing to this phenomenon, high-performance liquid chromatography/mass spectrometry-based proteomic analysis was conducted with aqueous humor samples collected from 11 patients who underwent cataract surgeries, with four patients diagnosed as RP and cataract (RP group) and the other seven with only senile cataract group. The upregulated proteins in the RP group were enriched in wound response, while downregulated proteins were enriched in cell adhesion and lens crystallins. Receptors of two dramatically upregulated proteins tenascin-C (TNC) and serotransferrin were found expressed in human lens epithelial cells (HLEs). TNC can promote primary HLEs proliferation and cell line HLE-B3 migration. This study indicates aqueous humor proteomic analysis serves as an effective way to unveil the pathogenesis of RP complications. TNC is a potential target of stimulating HLEs proliferation in RP concomitant cataract patients that worth further research.
机译：postcataract手术并发症的病人视网膜色素变性(RP)是镜头荚膜收缩。导致这一现象、高性能液相色谱/ spectrometry-based质量蛋白质组学分析与水进行幽默从11个病人收集的样本接受白内障手术,有四个病人诊断为RP和白内障(RP组)其他七个只有老年性白内障组。调节蛋白质RP组富含伤口反应,而表达下调蛋白质在细胞粘附和镜头丰富晶状体蛋白。调节蛋白质tenascin-C (TNC)和serotransferrin表达在人类中被发现晶状体上皮细胞(hl)。主要HLE-B3霍奇金淋巴瘤增殖和细胞线迁移。蛋白质组学分析作为一种有效的方法公布RP并发症的发病机理。是一个潜在的目标刺激霍奇金淋巴瘤RP伴随的白内障患者的扩散,值得进一步的研究。

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