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首页> 外文期刊>Journal of cellular physiology. >m~6A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer
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m~6A transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer

机译：m ~ 6转移酶METTL3-induced lncRNA ABHD11-AS1促进非小细胞的Warburg效应肺癌

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摘要

N~6-methyladenosine (m~6A) and long noncoding RNAs (lncRNAs) are both crucial regulators in non-small-cell lung cancer (NSCLC) tumorigenesis. However, the pathological roles of m~6A and lncRNAs in NSCLC progression are still limited and undefined. Here, lncRNA ABHD11-AS1 was upregulated in NSCLC tissue specimens and cells and the ectopic overexpression was closely correlated with unfavorable prognosis of NSCLC patients. Functionally, ABHD11-AS1 promoted the proliferation and Warburg effect of NSCLC. Mechanistically, m~6A profile was analyzed by methylated RNA immunoprecipitation sequencing (MeRIP-Seq). MeRIP-Seq presented that there was m~6A modification site in ABHD11-AS1. m~6A methyltransferase-like 3 (METTL3) installed the m~6A modification and enhanced ABHD11-AS1 transcript stability to increase its expression. In conclusion, our findings highlight the function and mechanism of METTL3-induced ABHD11-AS1 in NSCLC and inspire the understanding of m~6A and lncRNA in cancer biology.
机译：N ~ 6-methyladenosine (m ~ 6)和长非编码rna监管机构(lncRNAs)都是至关重要的非小细胞肺癌(NSCLC)肿瘤发生。然而,m ~ 6的病理作用lncRNAs在非小细胞肺癌的进展仍然有限和定义。在非小细胞肺癌组织标本和细胞调节和异位超表达是密切与非小细胞肺癌的预后不利病人。非小细胞肺癌的扩散和Warburg效应。分析了机械化,m ~ 6一个概要文件甲基化RNA免疫沉淀反应测序(MeRIP-Seq)。m ~ 6 ABHD11-AS1修改网站。methyltransferase-like 3 (METTL3)安装m ~ 6修改和增强ABHD11-AS1记录稳定增加其表达。总之,我们的研究结果表明METTL3-induced的功能和机制ABHD11-AS1在非小细胞肺癌和激励的理解的m ~ 6和lncRNA癌症生物学。

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