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首页> 外文期刊>Journal of cellular physiology. >Modulation of BAG3 expression in human normal urothelial cells by Diuron
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Modulation of BAG3 expression in human normal urothelial cells by Diuron

机译：调制BAG3表达在人类正常移行细胞细胞敌草隆

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摘要

Diuron [3-(3,4-dichlorophenyl)-l,l-dimethylurea] is a substituted urea herbicide, carcinogenic for the rat urinary bladder. It has been hypothesized that Diuron cytotoxicity, resulting in regenerative proliferation, leads to urothelial hyper-plasia and, finally, to bladder tumors, but molecular mechanisms of carcinogen-esis have not still fully investigated. Here, we report the results of a study aimed at verifying the involvement of BAG3, an intracellular protein expressed in several tumors, in the Diuron-induced carcinogenesis. For this purpose, we analyzed the effect of Diuron on human primary urothelial cells and on human dermal fibroblasts. We found that while high concentrations of Diuron have a cytotoxic effect in human primary urothelial cells, in the same cells, noncytotoxic concentrations of the herbicide induce BAG3 expression. These findings show that BAG3 is a molecular target of Diuron and unravel the possible involvement of BAG3 protein in bladder carcinogenesis induced by the herbicide. In addition, these results suggest that BAG3 might be a potential early biomarker of damage induced by chronic exposure to Diuron.
机译：Diuron [3 - (3,4-dichlorophenyl) -, l-dimethylurea]是一个取代脲类除草剂,致癌大鼠膀胱。敌草隆细胞毒性,导致再生增殖,导致移行细胞hyper-plasia,最后,膀胱肿瘤,但是carcinogen-esis没有的分子机制仍然全面调查。的一项研究结果,旨在验证BAG3的参与细胞内的蛋白质表示在一些肿瘤中Diuron-induced致癌作用。我们分析了敌草隆人类主要的影响泌尿道上皮细胞和人类皮肤成纤维细胞。我们发现,而高浓度的敌草隆人类主要有细胞毒性的影响泌尿道上皮细胞,在相同的细胞,noncytotoxic除草剂的浓度诱导BAG3表达式。敌草隆和瓦解的分子目标可能BAG3蛋白质参与膀胱引起的致癌作用的除草剂。此外,这些结果表明,BAG3可能是一个潜在的损伤诱导的早期生物标志物慢性暴露于敌草隆。

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