Two neuroendocrine G protein-coupled receptor molecules, somatostatin and melatonin: Physiology of signal transduction and therapeutic perspectives

Eva Costanzi; Carolina Simioni; laria ContiIlaria LafaceGabriele VaranoCinzia BrennaLuca M. Neri

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Two neuroendocrine G protein-coupled receptor molecules, somatostatin and melatonin: Physiology of signal transduction and therapeutic perspectives

机译：两个神经内分泌G protein-coupled受体分子,生长激素抑制素和褪黑激素:生理学的信号转导和治疗视角

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Recent studies have shown that G protein-coupled receptors (GPCRs), the largest signal-conveying receptor family, are targets for mutations occurring frequently in different cancer types. GPCR alterations associated with cancer development represent significant challenges for the discovery and the advancement of targeted therapeutics. Among the different molecules that can activate GPCRs, we focused on two molecules that exert their biological actions regulating many typical features of tumorigenesis such as cellular proliferation, survival, and invasion: somatostatin and melatonin. The modulation of signaling pathways, that involves these two molecules, opens an interesting scenario for cancer therapy, with the opportunity to act at different molecular levels. Therefore, the aim of this review is the analysis of the biological activity and the therapeutic potential of somatostatin and melatonin, displaying a high affinity for GPCRs, that interfere with cancer development and maintenance.

机译：最近的研究表明,G protein-coupled受体(GPCRs),最大的信号传递受体家族,目标突变经常发生在不同癌症类型。GPCR的改变与癌症有关发展代表了重大的挑战目标的发现和进步疗法。可以激活GPCRs,我们集中在两个分子发挥其生物行为规范等肿瘤发生的典型特征细胞增殖、生存和入侵:生长激素抑制素和褪黑激素。这两个信号通路,包括分子,打开一个有趣的场景癌症治疗,采取行动的机会不同的分子水平。本文的分析是生物活动与治疗的潜力生长激素抑制素和褪黑激素,显示高亲和力GPCRs,干扰癌症开发和维护。

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来源
《Journal of cellular physiology.》 |2021年第4期|2505-2518|共14页
作者
Eva Costanzi; Carolina Simioni; laria ContiIlaria LafaceGabriele VaranoCinzia BrennaLuca M. Neri;
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Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy;

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正文语种英语
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Signal Transduction; Melatonin; Molecular Targeted TherapySomatostatinG-Protein-Coupled ReceptorsCancercancer therapyTumours;

机译：信号转导;褪黑素分子的目标TherapySomatostatinG-Protein-CoupledReceptorsCancercancer therapyTumours;

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Two neuroendocrine G protein-coupled receptor molecules, somatostatin and melatonin: Physiology of signal transduction and therapeutic perspectives

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