ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19

Mitrasadat Rezaei; Seyed Ali Ziai; Sajad FakhriRamin Pouriran

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ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19

机译：ACE2:严重的潜在作用和监管急性呼吸系统综合症和COVID-19

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COVID-19, a new disease caused by the 2019-novel coronavirus (SARS-CoV-2), has swept the world and challenged its culture, economy, and health infrastructure. Forced emergence to find an effective vaccine to immunize people has led scientists to design and examine vaccine candidates all over the world. Until a vaccine is developed, however, effective treatment is needed to combat this virus, which is resistant to all conventional antiviral drugs. Accordingly, more about the structure, entry mechanism, and pathogenesis of COVID-19 is required. Angiotensin-converting enzyme 2 (ACE2) is the gateway to SARS-CoV and SARS-CoV-2, so our knowledge of SARS-CoV-2 can help us to complete its mechanism of interaction with ACE2 and virus endocytosis, which can be interrupted by neutralizing small molecules or proteins. ACE2 also plays a crucial role in lung injury.

机译：COVID-19,造成一种新的疾病2019 -小说冠状病毒(SARS-CoV-2),席卷世界挑战它的文化、经济、和健康基础设施。有效的疫苗接种的人了科学家们设计和研究疫苗世界各地的候选人。然而,开发有效的治疗是必要的对抗这种病毒,这是抵抗传统的抗病毒药物。关于结构,输入机制,发病机理的COVID-19是必需的。血管紧张素转换酶2 (ACE2)是通往冠和SARS-CoV-2,所以我们的SARS-CoV-2知识可以帮助我们来完成其与ACE2互动机制和病毒内吞作用,可以打断了中和小分子或蛋白质。也在肺损伤中起着至关重要的作用。

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来源
《Journal of cellular physiology.》 |2021年第4期|2430-2442|共13页
作者
Mitrasadat Rezaei; Seyed Ali Ziai; Sajad FakhriRamin Pouriran;
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作者单位

Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran;

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原文格式 PDF
正文语种英语
中图分类
关键词
Lung Injury; SARS coronavirus; MicroRNAsVaccinesRespiratory Syndrome, Acute, SevereACE2 geneAdult Respiratory Distress Syndromeangiotensin converting enzyme 2;

机译：冠状病毒;MicroRNAsVaccinesRespiratory综合症,急性,SevereACE2 geneAdult呼吸痛苦Syndromeangiotensin转换酶2;

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机译：成人呼吸促拍症候群（Acute Respiratory Distress Syndrome）－ Endotoxin吸着疗法の临床－
6. 成人呼吸促拍症候群（Acute Respiratory Distress Syndrome）－ Endotoxin吸着療法の臨床－ [J] . 津島健司, 高橋京子, 小泉知展, 診断と治療 . 2002,第4期

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7. 急性肺損傷／急性呼暇窮迫症候群（acute lung injury／acute respir atory distress syndrome；Au／ARDS） [J] . 丸山宗治日本内科学会雑誌 . 2008,第6期

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8. The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19 [O] . Mira Bosso, Thangavel Alphonse Thanaraj, Mohamed Abu-Farha, -1

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9. Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus [O] . Chen Z, Hu Z, Wang H, 2009

机译：angiotensin-converting enzyme 2 (aCE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus

ACE2: Its potential role and regulation in severe acute respiratory syndrome and COVID-19

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