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首页> 外文期刊>Journal of cellular physiology. >Factors inducing transdifferentiation of myoblasts into adipocytes
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Factors inducing transdifferentiation of myoblasts into adipocytes

机译：成肌细胞的诱导分化转化的因素在脂肪细胞

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Fat infiltration in skeletal muscle is observed in several myopathies, is associated with muscular dysfunction, and is strongly correlated with insulin resistance, diabetes, obesity, and aging. In animal production, skeletal muscle fat (also known as intermuscular and intramuscular fat) is positively related to meat quality including tenderness, flavor, and juiciness. Thus, understanding the cell origin and regulation mechanism of skeletal muscle fat infiltration is important for developing therapies against human myopathies as well as for improving meat quality. Notably, age, sarcopenia, oxidative stress, injury, and regeneration can activate adipogenic differentiation potential in myoblasts and affect fat accumulation in skeletal muscle. In addition, several transcriptional and nutritional factors can directly induce trans-differentiation of myoblasts into adipocytes. In this review, we focused on the recent progress in understanding the muscle-to-adipocyte differentiation and summarized and discussed the genetic, nutritional, and physiological factors that can induce transdifferentiation of myoblasts into adipocytes. Moreover, the regulatory roles and mechanisms of these factors during the transdifferentiation process were also discussed.
机译：脂肪浸润在骨骼肌中观察到几个肌肉疾病,与肌肉功能障碍,并强烈相关胰岛素抵抗、糖尿病、肥胖和衰老。在动物生产中,骨骼肌脂肪(也被称为肌间的和肌内脂肪)积极与肉类质量包括温柔、风味和多汁性。理解细胞起源和监管骨骼肌脂肪浸润机制重要的对人类发展疗法肌肉疾病以及改善肉品质。值得注意的是,年龄,sarcopenia,氧化应激,受伤,再生可以激活脂肪形成的在成肌细胞分化潜力和影响在骨骼肌脂肪堆积。几个转录和营养因素可以直接诱导trans-differentiation的成肌细胞向脂肪细胞。关注最近的研究进展muscle-to-adipocyte分化和总结和讨论了基因,营养和生理因素成肌细胞的诱导分化转移脂肪细胞。这些因素的机制分化转化过程进行了讨论。

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