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首页> 外文期刊>Journal of cellular physiology. >Dectin-1-mediated suppression of RANKL-induced osteoclastogenesis by glucan from baker's yeast
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Dectin-1-mediated suppression of RANKL-induced osteoclastogenesis by glucan from baker's yeast

机译：Dectin-1-mediated抑制RANKL-inducedosteoclastogenesis从面包酵母葡聚糖

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摘要

Immunoreceptors expressed on osteoclast precursor cells modify osteoclast differentiation and bone resorption activity. Dectin-1 is a lectin receptor of beta-glucan and is specifically expressed in osteoclast precursor cells. In this study, we evaluated the bioactivity of beta-glucan on receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and observed that glucan from baker's yeast inhibited this process in mouse bone marrow cells and dectin-1-overexpressing RAW264.7 (d-RAW) cells. In conjunction, RANKL-induced nuclear factor of activated T cell c1 expression was suppressed, subsequently downregulating TRAP and Oc-stamp. Additionally, nuclear factor-kappa B activation and the expression of c-fos and Blimp1 were reduced in d-RAW cells. Furthermore, glucan from baker's yeast induced the degradation of Syk protein, essential factor for osteoclastogenesis. These results suggest that glucan from baker's yeast suppresses RANKL-induced osteoclastogenesis and can be applied as a new treatment strategy for bone-related diseases.
机译：在破骨细胞前体Immunoreceptors表示修改破骨细胞分化和骨细胞吸收的活动。受体的葡聚糖和特别表示在破骨细胞前体细胞。研究中,我们评估的生物活性葡聚糖核受体激活factor-kappa B全身的配体(RANKL)osteoclastogenesis和观察到的葡聚糖在鼠标面包酵母抑制这一过程骨髓细胞和dectin-1-overexpressingRAW264.7细胞(d-RAW)。RANKL-induced核转录因子的激活T细胞c1表达被抑制,随后表达下调和Oc-stamp陷阱。核factor-kappa B激活和表达c-fos和Blimp1被减少d-RAW细胞。酵母诱导麦克米兰蛋白质的降解,osteoclastogenesis的至关重要的因素。结果表明,从面包酵母葡聚糖抑制RANKL-induced osteoclastogenesis和可以应用作为一种新的治疗策略骨疾病。

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