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首页> 外文期刊>Journal of cellular physiology. >Generation of biohybrid implants using a multipotent human periodontal ligament cell line and bioactive core materials
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Generation of biohybrid implants using a multipotent human periodontal ligament cell line and bioactive core materials

机译：代的合成体使用多功能人类牙周韧带细胞线和生物活性的核心材料

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摘要

We aimed to generate periodontal ligament (PDL) tissue-like structures from a multi-potent human PDL cell line using three-dimensional (3D) bioprinting technology and to incorporate these structures with bioactive core materials to develop a new biohybrid implant system. After 3D bioprinting, single-cell spheroids were able to form 3D tubular structures (3DTBs). We established three types of complexes using 3DTBs and different core materials: 3DTB-titanium core (TIC), 3DTB-hydroxyapatite core (HAC), and 3DTB without a core material (WOC). The expressions of PDL-, angiogenesis-, cementum-, and bone-related genes were significantly increased in the three complexes compared with monolayer-cultured cells. Abundant collagen fibers and cells positive for the above markers were confirmed in the three complexes. However, more positive cells were detected in HAC than in WOC or TIC. The present results suggest that 3D-bioprinted structures and hydroxyapatite core materials can function similarly to the PDL and may be useful for the development of a new biohybrid implant system.
机译：我们旨在生成牙周韧带(PDL)从多能人类组织如结构PDL细胞系使用三维(3 d)并将这些生物打印技术结构与生物活性的核心材料开发一个新的合成植入系统。生物打印,单细胞能够球状体形成三维管状结构(3防晒霜)。建立了三种类型的配合物3使用的防晒霜和不同的核心材料:3 dtb-titanium核心(TIC), 3 dtb-hydroxyapatite核心(HAC),和3的防晒霜没有一个核心材料(WOC)。PDL、血管生成、牙骨质和骨三个基因显著增加复合物与monolayer-cultured细胞。丰富的胶原纤维和细胞阳性上述三个标记被证实复合物。发现在HAC WOC或抽搐。结果表明,3 d-bioprinted结构和羟磷灰石核心材料的功能类似于自由人民党和可能是有用的发展新的合成植入系统。

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