Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons

Anna Kamynina

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Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons

机译：激活的愤怒导致的释放从星形胶质细胞谷氨酸刺激钙信号的神经元

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The receptor for advanced glycation end products (RAGE) is a signal receptor first shown to be activated by advanced glycation end products, but also by a variety of signal molecules, including pathological advanced oxidation protein products and (3-amyloid. However, most of the RAGE activators have multiple intracellular targets, making it difficult to unravel the exact pathway of RAGE activation. Here, we show that the cell-impermeable RAGE fragment sequence (60-76) of the V-domain of the receptor is able to activate RAGE present on the plasma membrane of neurons and, preferentially, astrocytes. This leads to the exocytosis of vesicular glutamate transporter vesicles and the release of glutamate from astrocytes, which stimulate NMDA and AMPA/kainate receptors, resulting in calcium signals predominantly in neurons. Thus, we show a specific mechanism of RAGE activation by the RAGE fragment and propose a mechanism by which RAGE activation can contribute to the neuronal-astrocytic communication in physiology and pathology.

机译：高级糖化受体的终端产品(愤怒)是一个信号受体首先显示由先进的糖化激活终端产品,但是也通过多种信号分子,包括病态的先进氧化蛋白质产品和(3-amyloid。催化剂有多个细胞内的目标,很难解决的途径愤怒的激活。cell-impermeable愤怒片段序列(60 - 76)的V-domain受体能够激活愤怒的质膜上优先神经元,星形胶质细胞。会导致水泡谷氨酸的胞外分泌转运囊泡和谷氨酸的释放星形胶质细胞,刺激NMDA和/ kainate AMPA受体,导致钙信号主要在神经元。具体的激活机制的愤怒愤怒的碎片并提出一种机制激活能做出贡献neuronal-astrocytic沟通生理学和病理。

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《Journal of cellular physiology.》 |2021年第9期|6496-6506|共11页
作者
Anna Kamynina;
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作者单位

Research Center for Molecular Mechanisms of Aging and Age Related Diseases, Moscow Institute of;

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正文语种英语
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Advanced Glycosylation End Product-Specific Receptor; Astrocyte; Calcium Signalingadvanced glycation end productGlutamatesAngerNeuronsPlasma membraneAdvanced Glycosylation End Productscalcium;

机译：高级糖基化结束特定于产品的受体,星形胶质细胞;钙Signalingadvanced糖化结束productGlutamatesAngerNeuronsPlasmamembraneAdvanced糖基化结束Productscalcium;

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Activation of RAGE leads to the release of glutamate from astrocytes and stimulates calcium signal in neurons

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