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首页> 外文期刊>Journal of cellular physiology. >The involvement of semaphorin 7 A in tumorigenic and immunoinflammatory regulation
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The involvement of semaphorin 7 A in tumorigenic and immunoinflammatory regulation

机译：semaphorin 7 A的参与肿瘤发生的和immunoinflammatory监管

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摘要

Semaphorins, a large group of highly conserved proteins, consist of eight subfamilies that are widely expressed in vertebrates, invertebrates, and viruses and exist in membrane-bound or secreted forms. First described as axon guidance cues during neurogenesis, semaphorins also perform physiological functions in other organ systems, such as bone homeostasis, immune response, and tumor progression. Semaphorin 7A (SEMA7A), also known as CDw108, is an immune semaphorin that modulates diverse immunoinflammatory processes, including immune cell interactions, inflammatory infiltration, and cytokine production. In addition, SEMA7A regulates the proliferation, migration, invasion, lymph formation, and angiogenesis of multiple types of tumor cells, and these effects are mediated by the interaction of SEMA7A with two specific receptors, PLXNC1 and integrins. Thus, SEMA7A is intimately related to the pathogenesis of multiple autoimmune and inflammation-related diseases and tumors. This review focuses on the role of SEMA7A in the pathogenesis of autoimmune disorders, inflammatory diseases, and tumors, as well as the underlying mechanisms. Furthermore, strategies targeting SEMA7A as a potential predictive, diagnostic, and therapeutic agent for these diseases are also addressed.
机译：Semaphorins,一大群高度保守的蛋白质,由八个亚科的广泛表达于脊椎动物、无脊椎动物,和病毒和存在于膜结合分泌形式。信号在神经发生,semaphorins也执行其他器官的生理功能系统,如骨内稳态,免疫响应和肿瘤进展。(也称为CDw108 SEMA7A)是一种免疫semaphorin,调节不同的immunoinflammatory流程,包括免疫细胞相互作用、炎症浸润和细胞因子的生产。调节扩散,迁移,入侵,淋巴生成和血管生成多个类型的肿瘤细胞,这些影响由SEMA7A两个之间的交互特定的受体,PLXNC1和整合蛋白。SEMA7A发病机制密切相关多种自身免疫和炎症相关疾病和肿瘤。SEMA7A在自身免疫性的发病机制中的作用障碍、炎性疾病和肿瘤潜在机制。针对SEMA7A作为一个潜在的战略预测、诊断和治疗代理这些疾病也解决。

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