The oncogenic and tumor suppressive roles of RNA-binding proteins in human cancers

Amirreza Bitaraf

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The oncogenic and tumor suppressive roles of RNA-binding proteins in human cancers

机译：的致癌基因和肿瘤抑制作用rna结合蛋白在人类癌症

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Posttranscriptional regulation is a mechanism for the cells to control gene regulation at the RNA level. In this process, RNA-binding proteins (RBPs) play central roles and orchestrate the function of RNA molecules in multiple steps. Accumulating evidence has shown that the aberrant regulation of RBPs makes contributions to the initiation and progression of tumorigenesis via numerous mechanisms such as genetic changes, epigenetic alterations, and noncoding RNA-mediated regulations. In this article, we review the effects caused by RBPs and their functional diversity in the malignant transformation of cancer cells that occurs through the involvement of these proteins in various stages of RNA regulation including alternative splicing, stability, polyadenylation, localization, and translation. Besides this, we review the various interactions between RBPs and other crucial posttranscriptional regulators such as microRNAs and long noncoding RNAs in the pathogenesis of cancer. Finally, we discuss the potential approaches for targeting RBPs in human cancers.

机译：转录后的调控机制控制基因调控的细胞RNA的水平。(RBPs)扮演核心角色和编排RNA分子的功能在多个步骤。越来越多的证据表明异常的监管RBPs贡献肿瘤发生的发生和发展许多基因变化等机制,表观遗传改变,非编码rna介导的规定。回顾RBPs及其造成的影响恶性的功能多样性癌细胞发生转变通过这些蛋白质参与的不同阶段RNA调控包括可变剪接、稳定性、聚腺苷酸化,本地化和翻译。审查各种RBPs和之间的相互作用其他重要的转录后的监管机构小分子核糖核酸和长非编码rna癌症的发病机理。针对RBPs人类潜在的方法癌症。

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《Journal of cellular physiology.》 |2021年第9期|6200-6224|共25页
作者
Amirreza Bitaraf;
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作者单位

Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University;

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原文格式 PDF
正文语种英语
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关键词
RNA-Binding Proteins; MicroRNAs; Long Intergenic Non-Protein Coding RNAcancer cellCancer;

机译：rna结合蛋白;小分子核糖核酸基因间的长非蛋白编码RNAcancer cellCancer;

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机译：Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Catechin; Cell Line, Tumor; Ceramides; Drug Synergism; Enzyme Activation; Humans; Ibuprofen; Male; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53;*脱噬作用; Caspase类; 儿茶素; 神经酰胺类; 药物协同作用; 酶激活; 布洛芬; 氧化性应激; 磷酰化; 前列腺肿瘤; 原致癌基因蛋白质 c-bcl-2
3. PD98059对H2O2诱导的人乳腺癌细胞凋亡及相关蛋白的影响 The Effect of the PD98059 on H2O2 Induced Apoptosis and Associated Proteins of Human Breast Cancer Cells [J] . Hans Journal of Biomedicine . 2011,第1期

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4. Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究 [J] . Acta Anaesthesiologica Scandinavica . 2009,第10期

机译：Adu; Aged;; Aged, 80 and over;; Cadherins;; Carcinoma, Squamous Cell;; Cell Nucleus;; Cytoplasm;; Female;; Humans;; Laryngeal Neoplasms;; Male;; Middle Aged;; Neoplasm Staging;; Protein-Serine-Threonine Kinases;; Proto-Oncogene Proteins c-akt;; Retrospective Studies;; beta Catenin;; *成年人;; 老年人;; 老年人, 80以上;; 钙粘着糖蛋白类;; 癌, 鳞状细胞;; 细胞核;; 细胞质;; 喉肿瘤;; 肿瘤分期;; 蛋白质丝氨酸苏氨酸激酶;; 回顾性研究
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机译：Crystal structure-based exploration of the important role of arg106 in the RNa-binding domain of human coronavirus OC43 nucleocapsid protein

The oncogenic and tumor suppressive roles of RNA-binding proteins in human cancers

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